NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.


ABIN1001609 产品详细信息, 供应商: Log in to see
大肠杆菌(E. Coli)
Log in to see
Supplier Product No.
Log in to see

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

特异性 Scyllatoxin inhibits small conductance Ca2+-activated K+ channels (SK) 1-3.
产品特性 Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
Molecular formula: C142H237N45O39S7.
Disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28.
纯度 > 98 %
背景 Scyllatoxin inhibits SKCa3 channels heterologously expressed in HEK-293 cells. SKCa3 channel currents, before and after application of 100nM rScyllatoxin. The SKCa currents were elicited by 1µM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV.
分子量 3424
应用备注 20-200 nM

K+ channel toxin -KTx 5.1, Leiurotoxin I, LeTxI, ScyTx

限制 仅限研究用
状态 Lyophilized
溶解方式 Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.460ml will provide a stock solution of 10 M.
注意事项 Soluble in Water.
 image for rScyllatoxin (ABIN1001609) SKCa3 channel currents, before and after application of 100nM rScyllatoxin. The SKCa ...
有引用在: Rodríguez de la Vega, Possani: "Current views on scorpion toxins specific for K+-channels." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 865-75, 2004 (PubMed).

Pedarzani, Kulik, Muller, Ballanyi, Stocker: "Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones." in: The Journal of physiology, Vol. 527 Pt 2, pp. 283-90, 2000 (PubMed).

Strøbaek, Jørgensen, Christophersen, Ahring, Olesen: "Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells." in: British journal of pharmacology, Vol. 129, Issue 5, pp. 991-9, 2000 (PubMed).

Wadsworth, Doorty, Strong: "Comparable 30-kDa apamin binding polypeptides may fulfill equivalent roles within putative subtypes of small conductance Ca(2+)-activated K+ channels." in: The Journal of biological chemistry, Vol. 269, Issue 27, pp. 18053-61, 1994 (PubMed).

Grissmer, Lewis, Cahalan: "Ca(2+)-activated K+ channels in human leukemic T cells." in: The Journal of general physiology, Vol. 99, Issue 1, pp. 63-84, 1992 (PubMed).

Auguste, Hugues, Mourre, Moinier, Tartar, Lazdunski: "Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites." in: Biochemistry, Vol. 31, Issue 3, pp. 648-54, 1992 (PubMed).

Goh, Kelly, Pennefather, Chicchi, Cascieri, Garcia, Kaczorowski: "Effect of charybdotoxin and leiurotoxin I on potassium currents in bullfrog sympathetic ganglion and hippocampal neurons." in: Brain research, Vol. 591, Issue 1, pp. 165-70, 1992 (PubMed).

Auguste, Hugues, Gravé, Gesquière, Maes, Tartar, Romey, Schweitz, Lazdunski: "Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4753-9, 1990 (PubMed).

Chicchi, Gimenez-Gallego, Ber, Garcia, Winquist, Cascieri: "Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom." in: The Journal of biological chemistry, Vol. 263, Issue 21, pp. 10192-7, 1988 (PubMed).