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rScyllatoxin

ABIN1001609 产品详细信息, 供应商: Log in to see
适用
Scorpion
宿主
大肠杆菌(E. Coli)
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序列 AFCNLRMCQL SCRSLGLLGK CIGDKCECVK H.
特异性 Scyllatoxin inhibits small conductance Ca2+-activated K+ channels (SK) 1-3.
产品特性 Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
Molecular formula: C142H237N45O39S7.
Disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28.
纯度 > 98 %
背景 Scyllatoxin inhibits SKCa3 channels heterologously expressed in HEK-293 cells. SKCa3 channel currents, before and after application of 100nM rScyllatoxin. The SKCa currents were elicited by 1µM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV.
分子量 3424
应用备注 20-200 nM
说明

K+ channel toxin -KTx 5.1, Leiurotoxin I, LeTxI, ScyTx

限制 仅限研究用
状态 Lyophilized
溶解方式 Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.460ml will provide a stock solution of 10 M.
注意事项 Soluble in Water.
厂商提供的图像
 image for rScyllatoxin (ABIN1001609) SKCa3 channel currents, before and after application of 100nM rScyllatoxin. The SKCa ...
有引用在: Rodríguez de la Vega, Possani: "Current views on scorpion toxins specific for K+-channels." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 865-75, 2004 (PubMed).

Pedarzani, Kulik, Muller, Ballanyi, Stocker: "Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones." in: The Journal of physiology, Vol. 527 Pt 2, pp. 283-90, 2000 (PubMed).

Strøbaek, Jørgensen, Christophersen, Ahring, Olesen: "Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells." in: British journal of pharmacology, Vol. 129, Issue 5, pp. 991-9, 2000 (PubMed).

Wadsworth, Doorty, Strong: "Comparable 30-kDa apamin binding polypeptides may fulfill equivalent roles within putative subtypes of small conductance Ca(2+)-activated K+ channels." in: The Journal of biological chemistry, Vol. 269, Issue 27, pp. 18053-61, 1994 (PubMed).

Grissmer, Lewis, Cahalan: "Ca(2+)-activated K+ channels in human leukemic T cells." in: The Journal of general physiology, Vol. 99, Issue 1, pp. 63-84, 1992 (PubMed).

Auguste, Hugues, Mourre, Moinier, Tartar, Lazdunski: "Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites." in: Biochemistry, Vol. 31, Issue 3, pp. 648-54, 1992 (PubMed).

Goh, Kelly, Pennefather, Chicchi, Cascieri, Garcia, Kaczorowski: "Effect of charybdotoxin and leiurotoxin I on potassium currents in bullfrog sympathetic ganglion and hippocampal neurons." in: Brain research, Vol. 591, Issue 1, pp. 165-70, 1992 (PubMed).

Auguste, Hugues, Gravé, Gesquière, Maes, Tartar, Romey, Schweitz, Lazdunski: "Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4753-9, 1990 (PubMed).

Chicchi, Gimenez-Gallego, Ber, Garcia, Winquist, Cascieri: "Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom." in: The Journal of biological chemistry, Vol. 263, Issue 21, pp. 10192-7, 1988 (PubMed).