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rBeKm-1

ABIN1001604 产品详细信息, 供应商: Log in to see
适用
Scorpion
宿主
大肠杆菌(E. Coli)
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序列 RPTDIKCSES YQCFPVCKSR FGKTNGRCVN GFCDCF.
特异性 BeKm-1 inhibits ERG1 K+ channel currents and has minimal effect on ELK1 K+ channels.
产品特性 Source: Buthus eupeus (Lesser Asian scorpion).
Molecular formula: C174H267N51O52S6.
Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
纯度 > 98 %
背景 BeKm-1 inhibits Kv11.1 (hERG) channels expressed in HEK-293 cells. hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to -50 mV to +50 mV in 10 mV steps (1-s test potentials) from a holding potential of -80 mV for activation.
分子量 4092
应用备注 2-10 nM
说明

K+ channel toxin -KTx 2.1

限制 仅限研究用
状态 Lyophilized
溶解方式 Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.222ml will provide a stock solution of 10 M.
注意事项 Soluble in Water.
厂商提供的图像
 image for rBeKm-1 (ABIN1001604) hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel curr...
有引用在: Korolkova, Kozlov, Lipkin, Pluzhnikov, Hadley, Filippov, Brown, Angelo, Strøbaek, Jespersen, Olesen, Jensen, Grishin: "An ERG channel inhibitor from the scorpion Buthus eupeus." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9868-76, 2001 (PubMed).

Filippov, Kozlov, Pluzhnikov, Grishin, Brown: "M-type K+ current inhibition by a toxin fron the scorpion Buthus eupeus." in: FEBS letters, Vol. 384, Issue 3, pp. 277-80, 1996 (PubMed).