phosphofurin Acidic Cluster Sorting Protein 2 蛋白 (PACS2)

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. 再加上,我们可以发PACS2 抗体 (25)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
PACS2 23241 Q86VP3
PACS2 217893  
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Showing 4 out of 4 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10至12个工作日
$785.40
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$405.71
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PACS2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多phosphofurin Acidic Cluster Sorting Protein 2 (PACS2)互动伙伴

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

  2. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

  3. Tumor necrosis factor (显示 TNF 蛋白)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

  4. subcellular localization and function of polycystin-2 (显示 PKD2 蛋白) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2

  5. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

  6. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (显示 TG 蛋白)/endosomal system

  7. the phosphorylation state of the calnexin (显示 CANX 蛋白) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

  8. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (显示 AKT1 蛋白) cooperates with 14-3-3 (显示 YWHAQ 蛋白) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. CS-2 (显示 MYOZ1 蛋白) traffics to the nucleus where it regulates SIRT1 (显示 SIRT1 蛋白)-mediated p53 (显示 TP53 蛋白) deacetylation. PACS-2 binds SIRT1 (显示 SIRT1 蛋白) in vitro and directly inhibits SIRT1 (显示 SIRT1 蛋白)-catalyzed p53 (显示 TP53 蛋白) deacetylation.

  2. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (显示 TG 蛋白)/endosomal system

  3. Results identify PACS-2 as an essential TRAIL effector, and show that Akt (显示 AKT1 蛋白) cooperates with 14-3-3 (显示 YWHAQ 蛋白) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

蛋白简介PACS2

蛋白简介

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Gene names and symbols associated with PACS2

  • phosphofurin acidic cluster sorting protein 2 (PACS2)
  • phosphofurin acidic cluster sorting protein 2 (Pacs2)
  • 6720425G15Rik 蛋白
  • AW208651 蛋白
  • AW489976 蛋白
  • E230011J22 蛋白
  • mKIAA0602 蛋白
  • PACS-2 蛋白
  • Pacs1l 蛋白

Protein level used designations for PACS2

PACS1-like protein , PACS-2

GENE ID SPECIES
23241 Homo sapiens
217893 Mus musculus
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