helicase 2, X-linked (ATRX) ELISA试剂盒

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. 再加上,我们可以发ATRX 抗体 (104)ATRX 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 ATRX ATRX 546 P46100
大鼠 ATRX ATRX 246284  
小鼠 ATRX ATRX 22589 Q61687

适于 ATRX 相互作用对的更多 ELISA 试剂盒

Human helicase 2, X-linked (ATRX) interaction partners

  1. ATRX loss can be reliable for the pathogenesis of neuroendocrine pancreatic neoplasms.

  2. Mutation in ATRX gene is associated with cancer more frequently in males.

  3. Nek1 (显示 NEK1 ELISA试剂盒) phosphorylates Rad54 and regulates Rad51 (显示 RAD51 ELISA试剂盒) removal to orchestrate homologous recombination and replication fork stability.

  4. Results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of RAD51 (显示 RAD51 ELISA试剂盒) and RAD54 proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.

  5. ATRX interacts with ZNF274 (显示 ZNF274 ELISA试剂盒), TRIM28 (显示 TRIM28 ELISA试剂盒) and SETDB1 (显示 SETDB1 ELISA试剂盒) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (显示 ZNF274 ELISA试剂盒) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.

  6. somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome.

  7. AMab-6 sensitively detects ATRX in Western blot and immunohistochemical analyses, indicating that AMab-6 could become the standard marker to determine the ATRX mutation status of gliomas in immunohistochemical analyses

  8. our study describes a novel missense mutation of the ATRX gene helicase domain, carried by three affected males of the two generations of the same family and segregated with intellectual deficiency, dysmorphism and behaviour disorder without alpha-thalassaemia and with non-skewed X-chromosome inactivation

  9. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  10. ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (显示 TP53 ELISA试剂盒) overexpression as compared to patients with wild-type ATRX

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Our study highlights the importance of the cooperation between Rad54 (显示 RAD54L ELISA试剂盒) and Mus81 (显示 MUS81 ELISA试剂盒) for mediating DNA DSB repair and restraining chromosome missegregation.

  2. The long noncoding RNA, TERRA (显示 DMRT2 ELISA试剂盒) can bind both in cis (显示 CISH ELISA试剂盒) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (显示 DMRT2 ELISA试剂盒) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (显示 DMRT2 ELISA试剂盒) activates, ATRX represses gene expression.

  3. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  4. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  5. Daxx (显示 DAXX ELISA试剂盒) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (显示 HELLS ELISA试剂盒) levels are low.

  6. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  7. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

  8. ATRX promotes the incorporation of histone H3.3 (显示 H3F3A ELISA试剂盒) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.

  9. Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (显示 CISH ELISA试剂盒) along the X chromosome.

  10. These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.

ATRX 抗原简介

Antigen Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with ATRX

  • alpha thalassemia/mental retardation syndrome X-linked (ATRX) 抗体
  • alpha thalassemia/mental retardation syndrome X-linked (Atrx) 抗体
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx) 抗体
  • RAD54 like (S. cerevisiae) (Rad54l) 抗体
  • 4833408C14Rik 抗体
  • AI447451 抗体
  • ATR2 抗体
  • DXHXS6677E 抗体
  • HP1-BP38 抗体
  • Hp1bp2 抗体
  • Hp1bp38 抗体
  • JMS 抗体
  • MRXHF1 抗体
  • MRXS3 抗体
  • Rad54 抗体
  • RAD54L 抗体
  • SFM1 抗体
  • SHS 抗体
  • XH2 抗体
  • Xnp 抗体
  • ZNF-HX 抗体

Protein level used designations for ATRX

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus