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Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Cow (Bovine) Monoclonal CLTC Primary Antibody for ICC, FACS - ABIN152766
Fernandez, McVicker, Tuma, Tuma: Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. in Biochemical pharmacology 2009
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Cow (Bovine) Monoclonal CLTC Primary Antibody for WB - ABIN265878
Grossman, Ebke, Beight, Jang, Crabb, Hagstrom: Protein partners of dynamin-1 in the retina. in Visual neuroscience 2013
Human Polyclonal CLTC Primary Antibody for IF (p) - ABIN891159
Kuhn, Vanhecke, Michen, Blank, Gehr, Petri-Fink, Rothen-Rutishauser: Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages. in Beilstein journal of nanotechnology 2014
The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.
Inactivating epn-1 (显示 EPN1 抗体) or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1 (显示 EPN1 抗体), in an EPN-1 (显示 EPN1 抗体)-dependent manner.
These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.
Loss of SNX-1 (显示 SNX1 抗体), RME-8, or the clathrin chaperone Hsc70 (显示 HSPA8 抗体)/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 (显示 RAE1 抗体) to the lysosome.
Taken together, these results demonstrate that Japanese encephalitis virus enters porcine kidney epithelial PK15 cells through cholesterol- and clathrin-mediated endocytosis.
Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization
this study shows that clathrin, including the clathrin population associated to internal vesicles, controls lymphocyte migration by regulating actin rearrangements occurring at the leading age
The novel association of several endocytosis-associated proteins has been demonstrated, in particular, of CLTC and SCAMP3 (显示 SCAMP3 抗体) with hepatocellular carcinoma progression.
MiR (显示 MLXIP 抗体)-199a-5p suppresses tumorigenesis by targeting CLTC in hepatocellular carcinoma.
Data indicate that clathrin-mediated endocytosis of proto-oncogene (显示 RAB1A 抗体) protein erbB-3 (ErbB3 (显示 ERBB3 抗体)) is depending on epsin-1 (显示 EPN1 抗体).
SMAP2 (显示 BRD8 抗体) immunoprecipitated clathrin and AP-1 (显示 FOSB 抗体) through a putative clathrin-binding domain and a CALM-binding domain, and SMAP2 (显示 BRD8 抗体) mutants that did not interact with clathrin or AP-1 (显示 FOSB 抗体) could not localize to recycling endosomes
autophagy contributed to Cx31.1 (显示 GJB5 抗体) degradation, and clathrin might be involved in the autophagy of Cx31.1 (显示 GJB5 抗体).
Data suggest that by binding to both clathrin and F-actin, mammalian actin-binding protein 1 (mAbp1 (显示 DBNL 抗体); HIP-55 (显示 DBNL 抗体) or SH3P7 (显示 DBNL 抗体)) is specifically recruited at a late stage of clathrin-coated pits (CCPs) formation, which subsequently recruits dynamin (显示 DNM1 抗体) to CCPs.
In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway.
Our data support a model in which nascent Hepatits C Virus particles associate with apoE in the endoplasmic reticulum and exit cells following a clathrin-dependent transendosomal secretory route.
clathrin-mediated and caveolae-mediated endocytosis of VE-cad (显示 CDH5 抗体) contribute to lipopolysaccharide-induced vascular hyperpermeability.
three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.
Structure of clathrin coat with bound Hsc70 (显示 HSPA8 抗体) and auxilin (显示 DNAJC6 抗体).
clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
our results demonstrate that CKAP5 (显示 CKAP5 抗体) is important in oocyte maturation and early embryo development, and CKAP5 (显示 CKAP5 抗体) might work together with CLTC in mouse oocyte maturation
SP-A (显示 SFTPA1 抗体) transiently enhances the basal protein expression of CHC and alpha-adaptin (显示 AP2A2 抗体).
PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.
The clathrin-mediated endocytic machinery combines with Dab2 (显示 DAB2 抗体) to facilitate the endocytosis of RGD-integrin-beta3 clusters.
Taken together, these results show that CLTC plays an important role in spindle assembly and chromosome congression through a microtubule correlation mechanism during mouse oocyte maturation.
Auditory inner hair cells use dynamin-dependent endocytosis via clathrin-mediated endocytosis.
Data indicate that dynamin (显示 DNM1 抗体), clathrin, adaptor protein complex-2 (AP2 (显示 TFAP2A 抗体)), and amphiphysin (显示 AMPH 抗体) contribute to the depolarization-evoked entry in endocytosis.
This study reveals a novel functional role of clathrin-coated structure in GMR (显示 CSF2RA 抗体) signaling and the oncogenesis of JAK2V617F.
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.
study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
94 kDa B-raf protein
, B-Raf proto-oncogene serine/threonine-protein kinase (p94)
, murine sarcoma viral (v-raf) oncogene homolog B1
, proto-oncogene B-Raf
, serine/threonine-protein kinase B-raf
, v-raf murine sarcoma viral oncogene homolog B1
, clathrin heavy chain
, Clathrin Heavy Chain family member (chc-1)
, clathrin heavy chain 1
, clathrin heavy-chain
, clathrin, heavy polypeptide (Hc)
, clathrin heavy chain on chromosome 17
, clathrin, heavy polypeptide-like 2
, clathrin, heavy chain (Hc)
, clathrin, heavy chain (Hc) L homeolog