beta-Site APP-Cleaving Enzyme 1 (BACE) ELISA试剂盒

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. 再加上,我们可以发beta-Site APP-Cleaving Enzyme 1 抗体 (267)beta-Site APP-Cleaving Enzyme 1 蛋白 (34)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817

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0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 7至10个工作日
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小鼠 14.1 pg/mL 31.25-2000 pg/mL 96 Tests Log in to see 7至10个工作日
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大鼠 6.7 pg/mL 15.62-1000 pg/mL 96 Tests Log in to see 7至10个工作日
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1.0 ng/mL 1.0-250 ng/mL 96 Tests Log in to see 24至29个工作日
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0.31 ng/mL 0.78-50.0 ng/mL   96 Tests Log in to see 24至29个工作日
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1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 9至12个工作日
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豚鼠 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 9至12个工作日
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小鸡 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 6至8个工作日
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0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 6至8个工作日
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Pig 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 6至8个工作日
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引用最多的beta-Site APP-Cleaving Enzyme 1 ELISA试剂盒

  1. Human BACE ELISA Kit for Sandwich ELISA - ABIN365021 : Qian, Ding, Cheng, Zhu, Zhao, Jin, Guan, Zhang, Chen, Xu: Early biomarkers for post-stroke cognitive impairment. in Journal of neurology 2012 (PubMed)

适于 beta-Site APP-Cleaving Enzyme 1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. In conclusion, glucocorticoid couples mGR (显示 GRHL1 ELISA试剂盒) with Galphas (显示 GNAS ELISA试剂盒) and triggers cAMP-PKA-CREB (显示 CREB1 ELISA试剂盒) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (显示 APP ELISA试剂盒) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  2. study supports the hypothesis that Abeta (显示 APP ELISA试剂盒) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  3. Here, we demonstrate that Snapin (显示 SNAPIN ELISA试剂盒)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (显示 APP ELISA试剂盒) production. Adeno (显示 ADORA2A ELISA试剂盒)-associated virus-mediated Snapin (显示 SNAPIN ELISA试剂盒) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (显示 APP ELISA试剂盒) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  4. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (显示 GCG ELISA试剂盒)(11) to the Asp(1 (显示 BACE2 ELISA试剂盒)) site, resulting in much higher C99 level and C99/C89 ratio.

  5. SEPT8 (显示 SEPT8 ELISA试剂盒) modulates beta-amyloidogenic processing of APP (显示 APP ELISA试剂盒) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (显示 BIN1 ELISA试剂盒) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 ELISA试剂盒) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

  8. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (显示 APP ELISA试剂盒) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  9. analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP ELISA试剂盒) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  10. data indicate that Egr-1 (显示 EGR1 ELISA试剂盒) promotes Abeta (显示 APP ELISA试剂盒) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (显示 EGR1 ELISA试剂盒) plays role in activation of BACE-1 and acceleration of Abeta (显示 APP ELISA试剂盒) synthesis in AD brain.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  2. SEPT8 (显示 SEPT8 ELISA试剂盒) modulates beta-amyloidogenic processing of APP (显示 APP ELISA试剂盒) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  3. the depletion of BIN1 (显示 BIN1 ELISA试剂盒) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 ELISA试剂盒) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  4. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (显示 APP ELISA试剂盒) promotes beta-cleavage of APP (显示 APP ELISA试剂盒) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (显示 APP ELISA试剂盒).

  5. The circular RNA ciRS-7 promotes APP (显示 APP ELISA试剂盒) and BACE1 degradation in an NF-kappaB (显示 NFKB1 ELISA试剂盒)-dependent manner.

  6. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (显示 APOE ELISA试剂盒) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  7. analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP ELISA试剂盒) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  8. In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).

  9. findings demonstrate that USP8 (显示 USP8 ELISA试剂盒) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

  10. Cassia obtusifolia extract and its major constituents are potent BACE1 inhibitors.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (显示 BACE2 ELISA试剂盒) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) 抗原简介

Antigen Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) 抗体
  • beta-site APP-cleaving enzyme 1 (MGC145931) 抗体
  • beta-site APP-cleaving enzyme 1 (LOC100232107) 抗体
  • beta-site APP-cleaving enzyme 2 (bace2) 抗体
  • beta-site APP-cleaving enzyme 2 (BACE2) 抗体
  • beta-site APP-cleaving enzyme 2 (LOC100224177) 抗体
  • beta-site APP cleaving enzyme 1 (Bace1) 抗体
  • beta-site APP-cleaving enzyme 1 (bace1) 抗体
  • ASP2 抗体
  • BACE 抗体
  • BACE1 抗体
  • BACE2 抗体
  • C76936 抗体
  • HSPC104 抗体
  • MGC68482 抗体
  • MGC68881 抗体
  • MGC145931 抗体
  • zgc:77409 抗体

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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