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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. 再加上，我们可以发beta-Site APP-Cleaving Enzyme 1 抗体 (282) 和 beta-Site APP-Cleaving Enzyme 1 蛋白 (32)和数多这个蛋白质的别的产品。
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Lee, Park, Han: Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro. in Journal of microbiology (Seoul, Korea) 2007
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Human BACE ELISA Kit for Sandwich ELISA - ABIN1110850
Johnson, Drugan, Miller, Evans: 38 in 1991
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Human BACE ELISA Kit for Sandwich ELISA - ABIN365021
Qian, Ding, Cheng, Zhu, Zhao, Jin, Guan, Zhang, Chen, Xu: Early biomarkers for post-stroke cognitive impairment. in Journal of neurology 2012
Results indicate that SNX4 (显示 SNX4 ELISA试剂盒)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.
We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart
Study showed that serum deprivation enhances ADAM10 (显示 ADAM10 ELISA试剂盒)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.
Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.
SEPT8 (显示 SEPT8 ELISA试剂盒) modulates beta-amyloidogenic processing of APP (显示 APP ELISA试剂盒) through a mechanism affecting the intracellular sorting and accumulation of BACE1.
the depletion of BIN1 (显示 BIN1 ELISA试剂盒) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 ELISA试剂盒) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production
in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (显示 APP ELISA试剂盒) promotes beta-cleavage of APP (显示 APP ELISA试剂盒) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (显示 APP ELISA试剂盒).
The circular RNA ciRS-7 promotes APP (显示 APP ELISA试剂盒) and BACE1 degradation in an NF-kappaB (显示 NFKB1 ELISA试剂盒)-dependent manner.
rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (显示 APOE ELISA试剂盒) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.
analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP ELISA试剂盒) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites
study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (显示 CSF2 ELISA试剂盒) are suitable markers to monitor BACE1 inhibition in mice
Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.
In conclusion, glucocorticoid couples mGR (显示 GRHL1 ELISA试剂盒) with Galphas (显示 GNAS ELISA试剂盒) and triggers cAMP-PKA-CREB (显示 CREB1 ELISA试剂盒) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (显示 APP ELISA试剂盒) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.
study supports the hypothesis that Abeta (显示 APP ELISA试剂盒) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease
Here, we demonstrate that Snapin (显示 SNAPIN ELISA试剂盒)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (显示 APP ELISA试剂盒) production. Adeno (显示 ADORA2A ELISA试剂盒)-associated virus-mediated Snapin (显示 SNAPIN ELISA试剂盒) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (显示 APP ELISA试剂盒) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...
beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (显示 GCG ELISA试剂盒)(11) to the Asp(1 (显示 BACE2 ELISA试剂盒)) site, resulting in much higher C99 level and C99/C89 ratio.
In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (显示 BACE2 ELISA试剂盒) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
, asp 2
, aspartyl protease 2
, beta-secretase 1
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, membrane-associated aspartic protease 2
, transmembrane aspartic proteinase Asp2
, beta-site amyloid precursor protein cleaving enzyme 1
, beta-site APP cleaving enzyme
, beta secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-site APP-cleaving enzyme 1
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like