Vaccinia Related Kinase 1 (VRK1) ELISA试剂盒

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. 再加上,我们可以发Vaccinia Related Kinase 1 抗体 (73)Vaccinia Related Kinase 1 蛋白 (16)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
VRK1 7443 Q99986
VRK1 22367 Q80X41
大鼠 VRK1 VRK1 362779  

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Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (显示 TP53 ELISA试剂盒).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 AND VRK2 (显示 VRK2 ELISA试剂盒) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  2. VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (显示 CDK2 ELISA试剂盒) and p27(kip1 (显示 CDKN1B ELISA试剂盒)).

  3. we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma

  4. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (显示 FAM126A ELISA试剂盒).

  5. VRK1 is a novel regulator of CBs (显示 CBS ELISA试剂盒) dynamics and stability in cell cycle by protecting coilin (显示 COIL ELISA试剂盒) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  6. VRK1 regulation of NBS1 (显示 NBN ELISA试剂盒) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  7. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (显示 ATM ELISA试剂盒) Proteins.

  8. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (显示 APP ELISA试剂盒)). APP (显示 APP ELISA试剂盒) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (显示 APP ELISA试剂盒)-dependent mechanism.

  9. VRK1 can contribute to make these tumors more resistant to DNA damage-based therapies, such as ionizing radiation or doxorubicin, which is consistent with its association to a poor prognosis in ER positive breast cancer.

  10. VRK1 deficiency disrupts nuclear envelope morphology and leads to BAF (显示 BANF1 ELISA试剂盒) retention on mitotic chromosomes.

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (显示 APP ELISA试剂盒)). APP (显示 APP ELISA试剂盒) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (显示 APP ELISA试剂盒)-dependent mechanism.

  2. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  3. Protein kinase (显示 CDK7 ELISA试剂盒) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (显示 TP53 ELISA试剂盒)-dependent manner.

  4. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  5. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  6. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  7. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (显示 HIST3H3 ELISA试剂盒) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) 抗原简介

Antigen Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Gene names and symbols associated with VRK1

  • vaccinia related kinase 1 (vrk1) 抗体
  • vaccinia related kinase 1 (VRK1) 抗体
  • vaccinia related kinase 1 (LOC100340357) 抗体
  • Protein VRK-1 (vrk-1) 抗体
  • vaccinia related kinase 1 (Vrk1) 抗体
  • 51PK 抗体
  • MGC64390 抗体
  • MGC75762 抗体
  • PCH1 抗体
  • PCH1A 抗体
  • VRK1 抗体
  • wu:fe16f06 抗体
  • zgc:56266 抗体

Protein level used designations for VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

GENE ID SPECIES
380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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