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USP1 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. 再加上，我们可以发USP1 蛋白 (7)和数多这个蛋白质的别的产品。
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Human Polyclonal USP1 Primary Antibody for IP - ABIN257791
Lee, Yang, Cohn, Sikdar, DAndrea, Myung: Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. in The Journal of biological chemistry 2010
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Human Polyclonal USP1 Primary Antibody for IHC, IHC (p) - ABIN257792
Murai, Yang, Dejsuphong, Hirota, Takeda, DAndrea: The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. in Molecular and cellular biology 2011
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Human Polyclonal USP1 Primary Antibody for IHC, IHC (p) - ABIN4364533
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
USP1 is a key senescence regulator controlling genomic integrity.
High USP1 expression is associated with glioma.
USP1-UAF1 (显示 WDR48 抗体) complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 (显示 FANCD2 抗体) deubiquitination, as well as by interacting with RAD51AP1 (显示 RAD51AP1 抗体).
The results suggest that silencing USP1 inhibits cell proliferation and invasion in U2OS cells. Therefore, USP1 may provide a novel therapeutic target for the treatment of osteosarcoma.
Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance.
Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.
analysis of the function and regulation of the USP1-UAF1 (显示 WDR48 抗体) complex
USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)
No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA (显示 PCNA 抗体) in BAF180 (显示 PBRM1 抗体) expressing cells
USP1 phosphorylation at S313 is not critical for PCNA (显示 PCNA 抗体) deubiquitination, neither for binding to UAF1 (显示 WDR48 抗体) in a cellular environment.
our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1 (显示 ID1 抗体), and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality.
Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2 (显示 FANCD2 抗体)) and Pcna (proliferating cell nuclear antigen (显示 PCNA 抗体)).
Homozygous Uaf1 (显示 WDR48 抗体)(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded.
Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1 (显示 WDR48 抗体), an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway.
Bone marrow from Fancd2 (显示 FANCD2 抗体)-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.
mouse Usp1 functions downstream in the Fanconi anemia (显示 PALB2 抗体) pathway, and its deubiquitination is required for Fancd2 (显示 FANCD2 抗体) nuclear foci assembly
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
ubiquitin carboxyl-terminal hydrolase 1
, ubiquitin specific protease 1
, ubiquitin specific peptidase 1
, ubiquitin carboxyl-terminal hydrolase 1-like
, deubiquitinating enzyme 1
, ubiquitin carboxyl terminal hydrolase 1
, ubiquitin specific processing protease 1
, ubiquitin thioesterase 1
, ubiquitin thiolesterase 1
, ubiquitin-specific-processing protease 1
, ubiquitin specific peptdiase 1