anti-Troponin T2, Cardiac (TNNT2) 抗体

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. 再加上,我们可以发Cardiac Troponin T2 试剂盒 (72)Cardiac Troponin T2 蛋白 (36)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TNNT2 7139 P45379
TNNT2 24837 P50753
TNNT2 21956 P50752

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Showing 10 out of 381 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 24至29个工作日
¥3,074.65
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小鸡 小鼠 非结合性 IF, IHC (p) 0.1 mg Log in to see 29至35个工作日
¥4,893.43
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非结合性 EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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Cat 小鼠 非结合性 EIA, IHC (p), IP, WB 50 μg Log in to see 29至35个工作日
¥5,095.23
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Cow 小鼠 非结合性 EIA, WB   0.2 mg Log in to see 29至35个工作日
¥3,682.67
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小鼠 非结合性 EIA, IHC (p) 0.25 mg Log in to see 29至35个工作日
¥5,095.23
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小鼠 非结合性 IA, WB   0.2 mg Log in to see 25至31个工作日
¥2,272.67
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小鼠 非结合性 EIA, WB 0.2 mg Log in to see 29至35个工作日
¥3,985.39
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小鼠 非结合性 EIA, FACS, WB 0.1 mL Log in to see 29至35个工作日
¥4,691.64
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小鼠 非结合性 EIA, IHC (p) 0.25 mg Log in to see 29至35个工作日
¥5,095.23
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通过反应活性、应用领域、克隆类型和共轭标记 TNNT2 抗体

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引用最多的anti-Cardiac Troponin T2 抗体

  1. Human Polyclonal Cardiac Troponin T2 Primary Antibody for EIA, WB - ABIN951043 : Millat, Chanavat, Créhalet, Rousson: Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy. in Clinica chimica acta; international journal of clinical chemistry 2010 (PubMed)
    Show all 3 references for 951043

  2. Cow (Bovine) Polyclonal Cardiac Troponin T2 Primary Antibody for WB - ABIN2776953 : Klaassen, Probst, Oechslin, Gerull, Krings, Schuler, Greutmann, Hürlimann, Yegitbasi, Pons, Gramlich, Drenckhahn, Heuser, Berger, Jenni, Thierfelder: Mutations in sarcomere protein genes in left ventricular noncompaction. in Circulation 2008 (PubMed)

  3. Human Monoclonal Cardiac Troponin T2 Primary Antibody for IA, WB - ABIN265695 : Qiao, Tang, Munske, Dutta, Ivory, Dong: Enhanced fluorescence anisotropy assay for human cardiac troponin I and T detection. in Journal of fluorescence 2011 (PubMed)

  4. Human Monoclonal Cardiac Troponin T2 Primary Antibody for EIA, FACS - ABIN1105666 : Hershberger, Pinto, Parks, Kushner, Li, Ludwigsen, Cowan, Morales, Parvatiyar, Potter: Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. in Circulation. Cardiovascular genetics 2009 (PubMed)

  5. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody for IF, IHC (p) - ABIN180606 : Malouf, McMahon, Oakeley, Anderson: A cardiac troponin T epitope conserved across phyla. in The Journal of biological chemistry 1992 (PubMed)

更多抗Cardiac Troponin T2的相互作用对抗体

Human Troponin T2, Cardiac (TNNT2) interaction partners

  1. Higher postoperative concentrations of high-sensitivity troponin T are independently associated with all-cause mortality in patients undergoing on-pump cardiac surgery.

  2. variants in TNNT2 and BAG3 (显示 BAG3 抗体) are associated with a high propensity to life-threatening cardiomyopathy presenting from childhood and young adulthood.

  3. Binding of the MBNL (显示 MBNL1 抗体) zinc fingers to cardiac troponin T pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  4. The measurement of high-sensitivity cardiac troponin T plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.

  5. Data suggest that modulation of structural dynamics far from the regulatory Ca2 (显示 CA2 抗体)+-binding site is the underlying molecular mechanism for many TNNC1 (显示 TNNC1 抗体) mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (显示 TNNI2 抗体)(SW)] switch peptide binds to TNNC1 (显示 TNNC1 抗体) and stabilizes the open TNNC1 (显示 TNNC1 抗体) conformation.

  6. Data suggest that the tropomyosin (显示 TPM2 抗体) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2, R92L) that is associated with hypertrophic cardiomyopathy.

  7. High T2-weighted signal intensity on cine MRI is associated with elevated troponin T in hypertrophic cardiomyopathy.

  8. The high negative predictive value of preoperative hs-cTnT and NT-proBNP suggest usefulness as a "rule-out" test to confirm low risk of postoperative Myocardial Infarction

  9. Generated is a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in human Tnnt2. Tnnt2 R141W mutation causes a Ca2 (显示 CA2 抗体)+ desensitization and mice adapt by increasing Ca2 (显示 CA2 抗体)+-transient amplitudes, which impairs Ca2 (显示 CA2 抗体)+ handling dynamics, metabolism and responses to beta-adrenergic activation.

  10. A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Significant changes in thin filament Ca2 (显示 CA2 抗体)+-sensitivity, structure and kinetics are brought about through PKC (显示 PKC 抗体) phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Rabbit Troponin T2, Cardiac (TNNT2) interaction partners

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Mouse (Murine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. TnTA30V mutation attenuated Ca(2 (显示 CA2 抗体)+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin (显示 MYH6 抗体) heavy chain but augmented these parameters against beta-myosin heavy chain (显示 MYH7 抗体), suggesting divergent contractile phenotypes.

  2. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A (显示 DYRK1A 抗体) overexpression.

  3. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT (显示 TNNI1 抗体), Ca(2 (显示 CA2 抗体)+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  4. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain (显示 MYH7 抗体)

  5. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  6. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  7. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  8. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  9. TnT (显示 TNNI1 抗体) mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 (显示 MYH6 抗体) and hypertrophic cardiomyopathy in the presence of MYH7 (显示 MYH7 抗体).

  10. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

Zebrafish Troponin T2, Cardiac (TNNT2) interaction partners

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1 (显示 TNNI1 抗体), Tnnt2, and Tnnt3b were conserved in the central tropomyosin (显示 TPM2 抗体)- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 (显示 TNNI1 抗体) and Tnnt2, but not Tnnt3b.

Cardiac Troponin T2 (TNNT2) 抗原简介

蛋白简介

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Gene names and symbols associated with TNNT2

  • troponin T type 2 (cardiac) (TNNT2) 抗体
  • troponin T2, cardiac (Tnnt2) 抗体
  • troponin T type 2 (cardiac) (Tnnt2) 抗体
  • troponin T type 2 (cardiac) (tnnt2) 抗体
  • troponin T2a, cardiac (tnnt2a) 抗体
  • CMH2 抗体
  • CMPD2 抗体
  • CT3 抗体
  • cTnT 抗体
  • Ctt 抗体
  • CTTG 抗体
  • LVNC6 抗体
  • RATCTTG 抗体
  • RCM3 抗体
  • tnnt2 抗体
  • Tnnt3 抗体
  • Tnt 抗体
  • TnTC 抗体

Protein level used designations for TNNT2

troponin T, cardiac muscle , troponin T2, cardiac , cardiac troponin 2 , cardiac troponin T , troponin T type 2, cardiac , cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , Troponin T cardiac , cTnT , cardiac muscle troponin T , cardiac troponin T2 , tnTc , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , Troponin T, cardiac muscle , troponin T cardiac isoform , cardiac TnT , sih , silent heart

GENE ID SPECIES
493940 Felis catus
100379561 Cavia porcellus
403532 Canis lupus familiaris
7139 Homo sapiens
24837 Rattus norvegicus
398518 Xenopus laevis
396433 Gallus gallus
100622450 Sus scrofa
286816 Bos taurus
100009428 Oryctolagus cuniculus
21956 Mus musculus
58071 Danio rerio
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