anti-Tripeptidyl Peptidase II (Tpp2) 抗体

Tpp2 encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. 再加上,我们可以发Tpp2 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
Tpp2 7174 P29144
Tpp2 22019 Q64514
Tpp2 81815 Q64560

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-TPP2 Antibody Titration: 1.0 ug/ml Positive Control: Jurkat Whole Cell TPP2 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 5至7个工作日
¥20,898.73
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小鸡 非结合性 WB   100 μL Log in to see 24至30个工作日
¥3,622.12
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豚鼠 非结合性 WB   50 μg Log in to see 29至35个工作日
¥5,538.93
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非结合性 ICC, IF Immunocytochemistry/Immunofluorescence: Tripeptidyl peptidase II Antibody  - Staining of human cell line RH-30 shows localization to nuclear bodies & cytosol. 100 μL Log in to see 28至35个工作日
¥3,591.24
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非结合性 IHC, IHC (p), WB Western Blot: Tripeptidyl peptidase II Antibody  - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II. Western Blot: Tripeptidyl peptidase II Antibody  - Analysis in human cell line Jurkat. 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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非结合性 IC, IF, IHC, WB Immunofluorescent analysis of TPP2 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of TPP2 staining in mouse lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the ant 200 μL Log in to see 7至8个工作日
¥3,981.76
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非结合性 IHC, WB Western blot analysis of extracts of various cell lines, using TPP2 antibody. Immunohistochemistry of paraffin-embedded Mouse lung using TPP2 antibody at dilution of 1:100 (x400 lens). 100 μL Log in to see 34至38个工作日
¥2,882.69
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非结合性 IF, IHC, WB   50 μL Log in to see 29至35个工作日
¥4,028.97
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非结合性 IF, IHC, ELISA, WB   50 μL Log in to see 7至10个工作日
¥2,864.83
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非结合性 IHC (p), WB   100 μL Log in to see 29至34个工作日
¥4,116.53
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通过反应活性、应用领域、克隆类型和共轭标记 Tpp2 抗体

特性 应用范围 宿主 克隆类型
Human ,
,

Mouse (Murine)


Rat (Rattus)


更多抗Tpp2的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  2. a systematic kinetic analysis of wild type Drosophila melanogaster TPPII and five point mutants of the double-Glu (显示 SLC2A1 抗体)-motif (E312/E343) involving natural substrates were performed.

  3. The structure suggests a model for activation of TPP II involving the relocation of a flexible loop and a repositioning of the active-site serine, coupling it to holocomplex assembly and active-site sequestration.

  4. The 150 kDa subunits of TPPII form a superstructure composed of 2 segmented & twisted (显示 POMT2 抗体) strands. Each strand is 12.5 nm in width & composed of 11 segments that enclose a central channel.

  5. the unique spindle form of the holo-complex of TPP II represents an assembly motif stabilizing a highly active state

Arabidopsis thaliana Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. The purification and characterization of tripeptidyl peptidase II from Arabidopsis thaliana is reported.

Human Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Novel interactions of TPPII, p53 (显示 TP53 抗体), and SIRT7 (显示 SIRT7 抗体) presented in this study might contribute to the knowledge of the regulatory effects of these proteins on apoptotic pathways and to the understanding mechanisms of aging and lifespan regulation.

  2. TPP2 mediates many important cellular functions by controlling ERK1 (显示 MAPK3 抗体) and ERK2 (显示 MAPK1 抗体) phosphorylation.

  3. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with TPP2 deficiency have been described in two consanguineous siblings.

  4. Study found that autosomal recessive TPP2 mutations cause recurrent infections, autoimmunity, and neurodevelopmental delay in humans.

  5. TPPII, MYBBP1A (显示 MYBBP1A 抗体) and CDK2 (显示 CDK2 抗体) form a protein-protein interaction network.

  6. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  7. Study showed that overexpression of Tripeptidyl peptidase II (TPP2) occurs frequently during oral carcinogenesis and might be associated with the progression of Oral Squamous Cell Carcinoma (OSCC) via Spindle Assembly Checkpoint(SAC (显示 ADCY10 抗体)) activation.

  8. obtained a 3D structure of the human TPPII

  9. Current knowledge about TPPII with a focus on structural aspects.

  10. Results suggest an important function of TPPII in the maintenance of viral growth and may have implications for anti-viral therapy.

Mouse (Murine) Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2 (显示 CA2 抗体)+) stores via the type 3 RyR (显示 RYR1 抗体).

  2. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  3. Tripeptidyl peptidase II is crucial for nucleoprotein epitope generation during major histocompatibility complex class I complex viral antigen processing both in the presence and absence of lactacystin-sensitive proteasome action.

  4. TPPII is not generally required for the production of major histocompatibility class I-restricted peptides, but presentation of some peptides can be negatively affected by TPPII.

  5. Data show that mice that were homozygous for an insertion in the Tpp2 locus were embryonic lethal and Tpp2 heterozygous mutants were lean compared with wild-type littermates, although food intake was normal.

  6. The data suggest a moderate, predominantly destructive role of TPPII in class I Ag processing.

  7. TPPII is important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPPII inhibitors

  8. These results do not support a generally important role of TPPII for viability and proliferation of transformed cells or their p53 (显示 TP53 抗体)-mediated DNA damage response.

  9. These data indicate that while TPPII contributes to the trimming of peptides with very long N-terminal extensions, TPPII is not essential for generating most MHC class I-presented peptides or for stimulating CTL responses to several Ags (显示 GLA 抗体) in vivo.

Tpp2 抗原简介

蛋白简介

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase\; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.

Gene names and symbols associated with Tpp2

  • tripeptidyl-peptidase II (TppII) 抗体
  • tripeptidyl peptidase II (TPP2) 抗体
  • tripeptidyl peptidase II (tpp2) 抗体
  • tripeptidyl peptidase ii (AaeL_AAEL007174) 抗体
  • tripeptidyl peptidase ii (AaeL_AAEL009516) 抗体
  • tripeptidyl peptidase ii (AaeL_AAEL010192) 抗体
  • tripeptidyl peptidase II (LOC100359134) 抗体
  • tripeptidyl peptidase II (Tpp2) 抗体
  • anon-WO0118547.127 抗体
  • CG3991 抗体
  • DKFZp468E2313 抗体
  • Dmel\\CG3991 抗体
  • dTPP II 抗体
  • dTPPII 抗体
  • l(2)k14301 抗体
  • MGC83244 抗体
  • T13K14.10 抗体
  • T13K14_10 抗体
  • TPP-2 抗体
  • TPP2 抗体
  • TPP II 抗体
  • TppII 抗体
  • tripeptidyl peptidase ii 抗体

Protein level used designations for Tpp2

CG3991-PA , CG3991-PD , TppII-PA , TppII-PD , Tripeptidyl-peptidase II , tripeptidyl peptidase II , tripeptidylpeptidase II , tripeptidyl peptidase ii , tripeptidyl-peptidase 2 , TPP-II , tripeptidyl aminopeptidase , tripeptidyl-peptidase II

GENE ID SPECIES
36444 Drosophila melanogaster
428020 Gallus gallus
443806 Xenopus laevis
827833 Arabidopsis thaliana
5568882 Aedes aegypti
5572106 Aedes aegypti
5572975 Aedes aegypti
100101674 Xenopus (Silurana) tropicalis
100172493 Pongo abelii
100359134 Oryctolagus cuniculus
100552517 Anolis carolinensis
7174 Homo sapiens
22019 Mus musculus
81815 Rattus norvegicus
526052 Bos taurus
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