Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) ELISA试剂盒

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. 再加上,我们可以发TREM2 抗体 (192)TREM2 蛋白 (14)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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25.5 pg/mL 62.5 pg/mL - 4000 pg/mL 96 Tests Log in to see 13至16个工作日
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小鼠 6.5 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Log in to see 13至16个工作日
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大鼠 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 13至16个工作日
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小鼠 29 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 8至12个工作日
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26.2 pg/mL 62.5 pg/mL - 4000 pg/mL   96 Tests Log in to see 8至12个工作日
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适于 TREM2 相互作用对的更多 ELISA 试剂盒

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Authors find, using a cell-free coat protein (显示 GOLPH3 ELISA试剂盒) complex II (COPII) vesicle budding reaction, that mutant TREM2 is exported efficiently from the ER. Mutant TREM2 becomes sensitive to cleavage by endoglycosidase D under conditions that inhibit recycling to the ER, indicating that it normally reaches a post-ER compartment.

  2. Mutations in TREM2 gene are known to cause Nasu-Hakola disease.

  3. TREM2 upregulation in the frontal cortex in AD is a late event and may not play a role early in the development of AD pathogenesis and the onset of clinical dementia.

  4. Our results suggest that TREM2 expression is increased in Alzheimer's disease and support previous findings that suggest that p.R47H variant affects TREM2 function by altering binding properties of the receptor rather than expression.

  5. Data show that protein-altering changes are in PLCG2 (显示 PLCG2 ELISA试剂盒), ABI3 (显示 ABI3 ELISA试剂盒), and TREM2 genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.

  6. Study found that rare variation in TREM2, including two variants within the extracellular Ig-like domain, may be associated with risk for Alzheimer's disease; suggests that impaired overall and cell surface expression of TREM2 may contribute to risk for Alzheimer's disease.

  7. Increased DNA methylation (显示 HELLS ELISA试剂盒) near TREM2 is seen in the superior temporal gyrus of patients with Alzheimer's disease

  8. Our work identifies the TREM2-APOE (显示 APOE ELISA试剂盒) pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.

  9. Found increased Alzheimer's disease risk associated with several TREM2 variants, and show that these variants decreased or markedly increased binding to TREM2 ligands. Results suggest that TREM2 signaling helps protect against Alzheimer's disease but can cause harm in excess, supporting the idea that proper TREM2 function is important to counteract disease progression.

  10. SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that cerebrospinal fluid soluble TREM2 levels could be an informative phenotype for Alzheimer disease

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults.

  2. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide.

  3. TREM2 and TREML2 (显示 TREML2 ELISA试剂盒) play opposite roles in microglia activation.

  4. Our study suggests that Vps35 (显示 vps35 ELISA试剂盒)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  5. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  6. This study demonstrate a critical role of TREM2-mediated Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  7. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  8. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  9. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression.

  10. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta (显示 APP ELISA试剂盒) plaque structure, thereby limiting neuritic damage.

TREM2 抗原简介

Antigen Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) 抗体
  • triggering receptor expressed on myeloid cells 2 (trem2) 抗体
  • trem-like transcript 2 protein (LOC100228399) 抗体
  • triggering receptor expressed on myeloid cells 2 (Trem2) 抗体
  • TREM-2 抗体
  • TREM-A1 抗体
  • TREM-B1 抗体
  • TREM2 抗体
  • Trem2a 抗体
  • Trem2b 抗体
  • Trem2c 抗体

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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