Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) ELISA试剂盒

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. 再加上,我们可以发TREM2 抗体 (192)TREM2 蛋白 (14)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  

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0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
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小鼠 6.5 pg/mL 15.6-1000 pg/mL 96 Tests Log in to see 7至10个工作日
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大鼠 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 7至10个工作日
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31 pg/mL 78-5000 pg/mL   96 Tests Log in to see 24至29个工作日
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小鼠 78-5000 pg/mL   96 Tests Log in to see 24至29个工作日
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Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that cerebrospinal fluid soluble TREM2 levels could be an informative phenotype for Alzheimer disease

  2. Rare coding variants of TREM2 may play an important role in AD in Han Chinese.

  3. These data demonstrate that cerebrospinal fluid soluble TREM2 levels are increased in the early symptomatic phase of Alzheimer's disease, probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.

  4. link three genetic risk factors for Alzheimer's disease and reveal a possible mechanism by which mutant TREM2 increases risk of AD

  5. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  6. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  7. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants

  8. silencing TREM-2 downregulated the expression levels of Bcl2 and PCNA, and upregulated the expression levels of Bax and caspase-3 in renal cell carcinoma cells. Depletion of TREM-2 inactivated PI3K/Akt pathway through increasing the expression of PTEN. TREM-2 acts as an oncogene in the development of renal cell carcinoma and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma.

  9. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

  10. this study shows that activation of TREM-2 may restrain h-MSC (显示 MSC ELISA试剂盒) immune activation and promote differentiation for tissue repair

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. TREM2 and TREML2 (显示 TREML2 ELISA试剂盒) play opposite roles in microglia activation.

  2. Our study suggests that Vps35 (显示 vps35 ELISA试剂盒)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  3. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  4. This study demonstrate a critical role of TREM2-mediated Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  5. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  6. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  7. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression.

  8. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta (显示 APP ELISA试剂盒) plaque structure, thereby limiting neuritic damage.

  9. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12 (显示 TYROBP ELISA试剂盒), both of which are expressed by microglia and have bee

  10. The authors demonstrate that a TREM2 loss-of-function mutation causes brain-wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism.

TREM2 抗原简介

Antigen Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) 抗体
  • triggering receptor expressed on myeloid cells 2 (trem2) 抗体
  • triggering receptor expressed on myeloid cells 2 (LOC100228399) 抗体
  • triggering receptor expressed on myeloid cells 2 (Trem2) 抗体
  • TREM-2 抗体
  • TREM-A1 抗体
  • TREM-B1 抗体
  • TREM2 抗体
  • Trem2a 抗体
  • Trem2b 抗体
  • Trem2c 抗体

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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