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TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. 再加上，我们可以发TRIP13 抗体 (76) 和 TRIP13 蛋白 (8)和数多这个蛋白质的别的产品。
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6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC (显示 ADCY10 ELISA试剂盒)), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC (显示 ADCY10 ELISA试剂盒) impairment.
Thes authors show that p31 (显示 ATP6V1E1 ELISA试剂盒)(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 (显示 MAD2L1 ELISA试剂盒) N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 (显示 MAD2L1 ELISA试剂盒) in the presence of ATP.
These results establish a paradigm of the roles of p31 (显示 ATP6V1E1 ELISA试剂盒)(comet) and TRIP13 in both checkpoint activation and inactivation.
the oligomeric form of TRIP13 binds both p31(comet) and MCC
TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
suggest that premature mitotic checkpoint (显示 BUB3 ELISA试剂盒) silencing triggered by TRIP13 overexpression may promote cancer development
propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation
TRIP13-deficient spermatocytes also progress to an H1t (显示 HIST1H1T ELISA试剂盒)-positive stage if ATM (显示 ATM ELISA试剂盒) activity is attenuated by hypomorphic mutations in Mre11 (显示 MRE11A ELISA试剂盒) or Nbs1 (显示 NBN ELISA试剂盒) or by elimination of the ATM (显示 ATM ELISA试剂盒)-effector kinase CHK2 (显示 CHEK2 ELISA试剂盒)
TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
HORMAD1 (显示 HORMAD1 ELISA试剂盒) and HORMAD2 (显示 HORMAD2 ELISA试剂盒) are depleted from synapsed chromosome axes with the help of TRIP13.
results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
TR-interacting protein 13 homolog
, TRIP-13 homolog
, pachytene checkpoint protein 2 homolog
, thyroid hormone receptor interactor 13 homolog
, thyroid receptor-interacting protein 13 homolog
, Thyroid hormone receptor interactor 13 homolog
, Thyroid receptor-interacting protein 13 homolog
, thyroid hormone receptor interactor 13
, thyroid receptor-interacting protein 13-like
, HPV16 E1 protein binding protein
, HPV16 E1 protein-binding protein
, TR-interacting protein 13
, human papillomavirus type 16 E1 protein-binding protein
, thyroid receptor interacting protein 13
, thyroid receptor-interacting protein 13
, Pachytene checkpoint protein 2 homolog
, Thyroid receptor-interacting protein 13