anti-Synuclein, alpha Interacting Protein (SNCAIP) 抗体

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. 再加上,我们可以发SNCAIP 蛋白 (6)SNCAIP 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SNCAIP 9627 Q9Y6H5
SNCAIP 307309  
SNCAIP 67847  

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Showing 10 out of 60 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, WB The anti-Synphilin-1 C-term Pab is used in Western blot to detect Synphilin-1 in mouse brain lysate. 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Rat brain lysates probed with Anti Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 100kD. Observed band size:60kD 100kD. 100 μL Log in to see 5至7个工作日
¥2,610.23
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非结合性 WB The anti-Synphilin-1 C-term Pab (ABIN390382) is used in Western blot to detect Synphilin-1 in mouse brain lysate. 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 IHC, WB Immunohistochemical analysis of Synphilin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Synphilin 1 expression in HeLa (A), U2OS (B) whole cell lysates. 200 μL Log in to see 7至8个工作日
¥3,941.44
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非结合性 ELISA, IHC, WB 100 μL Log in to see 34至38个工作日
¥4,371.67
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Alexa Fluor 594 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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HRP IHC (p), WB   100 μL Log in to see 14至17个工作日
¥3,555.98
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Cy7 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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FITC IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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Cy3 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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通过反应活性、应用领域、克隆类型和共轭标记 SNCAIP 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-SNCAIP 抗体

  1. Human Polyclonal SNCAIP Primary Antibody for IF, IHC (p) - ABIN2476664 : Büttner, Delay, Franssens, Bammens, Ruli, Zaunschirm, de Oliveira, Outeiro, Madeo, Buée, Galas, Winderickx: Synphilin-1 enhances ?-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. in PLoS ONE 2010 (PubMed)

更多抗SNCAIP的相互作用对抗体

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. Differential expression of synphilin-1 isoforms (and alpha-synuclein (显示 SNCA 抗体) and parkin (显示 PARK2 抗体)) was found in multiple system atrophy brains compared to control brain.

  2. Synphilin-1 binds ATP, but not CTP (显示 CDS1 抗体).

  3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

  4. Overexpression of SP1 (显示 PSG1 抗体) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (显示 PSG1 抗体) increased food intake but did not affect locomotor activity

  5. Although serine-129 phosphorylation of alpha-synuclein (显示 SNCA 抗体) facilitates tubulin polymerization promoting protein (TPPP (显示 Tppp 抗体))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

  6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

  7. Neuronal survival factor MEF2D (显示 MEF2D 抗体) is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein (显示 SNCA 抗体) accumulation and aggregation.

  8. Synphilin-1 inhibits alpha-synuclein (显示 SNCA 抗体) degradation by the proteasome.

  9. Knockdown of Herp (显示 HERPUD1 抗体) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

  10. Data show that periphilin (显示 PPHLN1 抗体) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (显示 PPHLN1 抗体) in PD.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. This study shows that alpha-synuclein (显示 SNCA 抗体) is present in cerebellar glutamatergic terminals.

  2. These results suggest that increased levels of NUB1 (显示 NPM3 抗体) play a potential role in degradation of detergent-insoluble alpha-synuclein (显示 SNCA 抗体) in vivo, although it is insufficient to degrade abnormal alpha-synuclein (显示 SNCA 抗体) in Lewy body disease model mice.

  3. SP1 (显示 SP1 抗体) results in a CCK (显示 CCK 抗体) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

  4. TEM (显示 TNMD 抗体) analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein (显示 SNCA 抗体), suggesting the therapeutic potential of the small molecule in PD.

  5. We exploited atomic force microscopy (AFM (显示 AFM 抗体)) for the selective, nanoscale confinement of alpha-Synuclein (显示 SNCA 抗体) on gold to study the early stages of alpha-Synuclein (显示 SNCA 抗体) aggregation and the effect of small molecules, like dopamine, on the aggregation process.

  6. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

  7. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

  8. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein (显示 SNCA 抗体) toxicity in vivo.

  9. synphilin-1 has a role in skill learning and motor performance

  10. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

SNCAIP 抗原简介

蛋白简介

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.

Gene names and symbols associated with SNCAIP

  • synuclein, alpha interacting protein (SNCAIP) 抗体
  • synuclein, alpha interacting protein (synphilin) (sncaip) 抗体
  • synuclein, alpha interacting protein (sncaip) 抗体
  • synuclein, alpha interacting protein (synphilin) (LOC100221074) 抗体
  • synuclein, alpha interacting protein (Sncaip) 抗体
  • synuclein, alpha interacting protein (synphilin) (Sncaip) 抗体
  • 2810407O15Rik 抗体
  • 4933427B05Rik 抗体
  • BB104594 抗体
  • LOC100221074 抗体
  • MGC88953 抗体
  • SNCAIP 抗体
  • Sph1 抗体
  • Syph1 抗体

Protein level used designations for SNCAIP

synuclein, alpha interacting protein , synuclein, alpha interacting protein (synphilin) , synphilin-1-like , alpha-synuclein-interacting protein , synphilin-1 , synuclein alpha interacting protein , synphilin-1 variant 1e

GENE ID SPECIES
100063985 Equus caballus
448237 Xenopus (Silurana) tropicalis
700372 Macaca mulatta
462021 Pan troglodytes
100406168 Callithrix jacchus
100481199 Ailuropoda melanoleuca
100559476 Anolis carolinensis
100221074 Taeniopygia guttata
9627 Homo sapiens
307309 Rattus norvegicus
426796 Gallus gallus
100720184 Cavia porcellus
67847 Mus musculus
481479 Canis lupus familiaris
100049698 Sus scrofa
540156 Bos taurus
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