Succinate Dehydrogenase Complex Assembly Factor 2 蛋白 (Sdhaf2)

Sdhaf2 encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. 再加上,我们可以发Sdhaf2 抗体 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
Sdhaf2 54949 Q9NX18
Sdhaf2 66072 Q8C6I2
Sdhaf2 361726 Q5RJQ7

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Sdhaf2 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

Rat (Rattus)

更多Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2)互动伙伴

Human Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) interaction partners

  1. Loss of SDHAF2 gene is associated with paragangliomas.

  2. The SDHA (显示 SDHA 蛋白), TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma.

  3. data show that SDHA (显示 SDHA 蛋白) flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism.

  4. FAD (显示 BRCA2 蛋白) interacts noncovalently with SDHA (显示 SDHA 蛋白) in the absence of SDH5

  5. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father.

  6. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD (显示 SDHD 蛋白) mRNA expression, which may be suggestive of a pathogenic role.

  7. New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients.

  8. Data indicate that SDH5 is protected from mitochondrial LON (显示 LONP1 蛋白) (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA (显示 SDHA 蛋白), a state that is dysregulated in hereditary paraganglioma 2 (PGL2).

  9. Data indicate that succinate dehydrogenase (显示 SDHA 蛋白) 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT (显示 ITK 蛋白)) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin (显示 CTNNB1 蛋白) signaling pathway.

  10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB (显示 SDHB 蛋白), SDHC (显示 SDHC 蛋白) and SDHD (显示 SDHD 蛋白) and the regulatory subunit gene SDHAF2 in many paraganglioma families.

蛋白简介Sdhaf2

蛋白简介

This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.

Gene names and symbols associated with Sdhaf2

  • succinate dehydrogenase complex assembly factor 2 (SDHAF2)
  • succinate dehydrogenase complex assembly factor 2 (LOC100353725)
  • succinate dehydrogenase complex assembly factor 2 (Sdhaf2)
  • succinate dehydrogenase complex assembly factor 2 (sdhaf2)
  • 0610038F07Rik 蛋白
  • AA407634 蛋白
  • AW049997 蛋白
  • C11orf79 蛋白
  • C14H11orf79 蛋白
  • PGL2 蛋白
  • RGD1309216 蛋白
  • SDH5 蛋白
  • wu:fj30e04 蛋白
  • zgc:163000 蛋白

Protein level used designations for Sdhaf2

succinate dehydrogenase complex assembly factor 2 , succinate dehydrogenase assembly factor 2, mitochondrial , SDH assembly factor 2 , Protein EMI5 homolog, mitochondrial , succinate dehydrogenase subunit 5, mitochondrial , hSDH5

GENE ID SPECIES
476065 Canis lupus familiaris
693401 Macaca mulatta
100173895 Pongo abelii
100353725 Oryctolagus cuniculus
54949 Homo sapiens
66072 Mus musculus
767983 Bos taurus
361726 Rattus norvegicus
569482 Danio rerio
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