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SLC5A5 encodes a member of the sodium glucose cotransporter family.
NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM (显示 ATM ELISA试剂盒)-mediated mechanisms.
Morphogenetic signals modify the expression of NIS and recovery response to MEK (显示 MAP2K1 ELISA试剂盒) inhibition.
Intracellular iodinated compounds affect NIS expression through the thyroid stimulating hormone-mediated cAMP-PKA and PLC (显示 PLC ELISA试剂盒)-IP3 pathways.
Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.
Cloning of the mouse sodium iodide symporter.
The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.
This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 (显示 ABCB4 ELISA试剂盒) shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.
The Na+/I- symporter mediates active iodide uptake in the intestine.
High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.
Results indicate that Na+/I- symporter (NIS) can be used as an objective used as an objective criterion for determining the sensitivity of luminal B and basal breast cancer (BC)subtypes to neoadjuvant chemotherapy (NACT (显示 SLC13A2 ELISA试剂盒)).
Our findings indicated that hTERT promoter-driven expression of the NIS gene in HeLa cells led to 188Re uptake and therapeutic effects. Thus, NIS-based gene therapy and imaging using the hTERT promoter and 188Re may be possible.
SLC5A5 was down-regulated in FTC (显示 FUT2 ELISA试剂盒) and PTC (显示 F9 ELISA试剂盒). Its expression could be modulated by hsa (显示 CD24 ELISA试剂盒)-let-7f-5p. ATC (显示 SRPK1 ELISA试剂盒) showed a loss of SLC5A5/hsa (显示 CD24 ELISA试剂盒)-let7f-5p correlation
Mutating the sites located on the C-terminal domain of the protein has no effect except for the creation of a diacidic motif that decreases the total NIS protein level without affecting its expression at the plasma membrane.
Therefore, enhancing functional NIS by the increasing level of glycosylation may be suggested as a promising therapeutic strategy for cancer patients who show refractory response to conventional radioiodine treatment.
Our results confirmed that NIS overexpression enhances the sensitivity of ER-negative breast cancer cells to radioiodide therapy.
miR (显示 MLXIP ELISA试剂盒)-146b-3p binds to the 3'-untranslated region of PAX8 (显示 PAX8 ELISA试剂盒) and sodium/iodide symporter, leading to impaired protein translation and a subsequent reduction in iodide uptake.
Study demonstrates an association of one variant and several haplotypes of the NIS gene with differentiated thyroid cancer.
Data suggest that SLC5A5, SLC5A8 (sodium-coupled monocarboxylate transporter 1 (显示 SLC5A8 ELISA试剂盒)), and SLC26A4 (pendrin (显示 SLC26A4 ELISA试剂盒)), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW]
Real time PCR revealed that both cell lines express mRNA of lactoferrin (显示 LTF ELISA试剂盒) receptors while flow cytometry and confocal microscopy showed the cells efficiently internalize bLf which upregulates NIS expression.
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
solute carrier family 5 (sodium iodide symporter), member 5
, sodium/iodide cotransporter
, sodium/iodide cotransporter-like
, solute carrier family 5 member 5
, sodium iodide symporter
, solute carrier family 5, member 5
, Na(+)/I(-) cotransporter
, Na(+)/I(-) symporter
, sodium-iodide symporter
, Na+/I- symporter