anti-Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) 抗体

SLC5A5 encodes a member of the sodium glucose cotransporter family.

列出全部抗体 基因 基因ID UniProt
小鼠 SLC5A5 SLC5A5 114479  
 SLC5A5 SLC5A5 6528 Q92911
大鼠 SLC5A5 SLC5A5 114613 Q63008

更多抗Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5的相互作用对抗体

Pig (Porcine) Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM (显示 ATM 抗体)-mediated mechanisms.

  2. Morphogenetic signals modify the expression of NIS and recovery response to MEK (显示 MAP2K1 抗体) inhibition.

  3. Intracellular iodinated compounds affect NIS expression through the thyroid stimulating hormone-mediated cAMP-PKA and PLC (显示 PLC 抗体)-IP3 pathways.

Mouse (Murine) Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.

  2. Cloning of the mouse sodium iodide symporter.

  3. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.

  4. This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 (显示 ABCB4 抗体) shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.

  5. The Na+/I- symporter mediates active iodide uptake in the intestine.

  6. High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.

Human Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. Results indicate that Na+/I- symporter (NIS) can be used as an objective used as an objective criterion for determining the sensitivity of luminal B and basal breast cancer (BC)subtypes to neoadjuvant chemotherapy (NACT (显示 SLC13A2 抗体)).

  2. Our findings indicated that hTERT promoter-driven expression of the NIS gene in HeLa cells led to 188Re uptake and therapeutic effects. Thus, NIS-based gene therapy and imaging using the hTERT promoter and 188Re may be possible.

  3. SLC5A5 was down-regulated in FTC (显示 FUT2 抗体) and PTC (显示 F9 抗体). Its expression could be modulated by hsa (显示 CD24 抗体)-let-7f-5p. ATC (显示 SRPK1 抗体) showed a loss of SLC5A5/hsa (显示 CD24 抗体)-let7f-5p correlation

  4. Mutating the sites located on the C-terminal domain of the protein has no effect except for the creation of a diacidic motif that decreases the total NIS protein level without affecting its expression at the plasma membrane.

  5. Therefore, enhancing functional NIS by the increasing level of glycosylation may be suggested as a promising therapeutic strategy for cancer patients who show refractory response to conventional radioiodine treatment.

  6. Our results confirmed that NIS overexpression enhances the sensitivity of ER-negative breast cancer cells to radioiodide therapy.

  7. miR (显示 MLXIP 抗体)-146b-3p binds to the 3'-untranslated region of PAX8 (显示 PAX8 抗体) and sodium/iodide symporter, leading to impaired protein translation and a subsequent reduction in iodide uptake.

  8. Study demonstrates an association of one variant and several haplotypes of the NIS gene with differentiated thyroid cancer.

  9. Data suggest that SLC5A5, SLC5A8 (sodium-coupled monocarboxylate transporter 1 (显示 SLC5A8 抗体)), and SLC26A4 (pendrin (显示 SLC26A4 抗体)), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW]

  10. Real time PCR revealed that both cell lines express mRNA of lactoferrin (显示 LTF 抗体) receptors while flow cytometry and confocal microscopy showed the cells efficiently internalize bLf which upregulates NIS expression.

Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) 抗原简介

蛋白简介

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.

Gene names and symbols associated with SLC5A5

  • solute carrier family 5 (sodium iodide symporter), member 5 (SLC5A5) 抗体
  • solute carrier family 5 (sodium iodide symporter), member 5 (slc5a5) 抗体
  • sodium iodide symporter (RB8797) 抗体
  • sodium iodide symporter (RB2501_13734) 抗体
  • sodium iodide symporter (CA2559_12043) 抗体
  • sodium iodide symporter (FB2170_10479) 抗体
  • solute carrier family 5 (sodium iodide symporter), member 5 (Slc5a5) 抗体
  • solute carrier family 5 (sodium/iodide cotransporter), member 5 (SLC5A5) 抗体
  • solute carrier family 5 (sodium/iodide cotransporter), member 5 (Slc5a5) 抗体
  • MGC84602 抗体
  • Nis 抗体
  • si:ch211-200a16.4 抗体
  • SLC5A5 抗体
  • TDH1 抗体

Protein level used designations for SLC5A5

solute carrier family 5 (sodium iodide symporter), member 5 , NIS , sodium/iodide cotransporter , sodium/iodide cotransporter-like , solute carrier family 5 member 5 , sodium iodide symporter , solute carrier family 5, member 5 , Na(+)/I(-) cotransporter , Na(+)/I(-) symporter , Na(+)/I(-)-symporter , sodium-iodide symporter , Na+/I- symporter

GENE ID SPECIES
431544 Gallus gallus
446726 Xenopus laevis
468767 Pan troglodytes
484830 Canis lupus familiaris
505310 Bos taurus
561445 Danio rerio
100144711 Xenopus (Silurana) tropicalis
100397857 Callithrix jacchus
100431462 Pongo abelii
100462701 Gasterosteus aculeatus
1794611 Rhodopirellula baltica SH 1
8456450 Robiginitalea biformata HTCC2501
9297898 Croceibacter atlanticus HTCC2559
9719699 Maribacter sp. HTCC2170
399542 Sus scrofa
114479 Mus musculus
6528 Homo sapiens
114613 Rattus norvegicus
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