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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. 再加上，我们可以发Solute Carrier Family 22 (Organic Cation Transporter), Member 2 蛋白 (6)和数多这个蛋白质的别的产品。
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Human Polyclonal SLC22A2 Primary Antibody for IHC, IHC (p) - ABIN4354103
Li, Cui, Jiang, Guo, Pishdari, Hu, Feng, Billig, Shao: Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. in American journal of translational research 2015
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Human Polyclonal SLC22A2 Primary Antibody for WB - ABIN4341324
Schmitt, Schäll, Bucher, Schindler, Hector, Biedermann, Zemlin, Hartl, Beer-Hammer: SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Rα-dependent mechanism in B-1 cells. in European journal of immunology 2015
Cow (Bovine) Polyclonal SLC22A2 Primary Antibody for WB - ABIN2781589
Pelis, Suhre, Wright: Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport. in American journal of physiology. Renal physiology 2006
we assessed the role of miR (显示 MLXIP 抗体)-21 in mediating renal cell carcinoma (显示 MOK 抗体) chemoresistance and further showed that miR (显示 MLXIP 抗体)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 (显示 SLC31A1 抗体) platinum influx transporter expression
Oct2 and Bob1 (显示 POU2AF1 抗体) are very reliable in determining B cell lineage in the absence of expression of other pan (显示 SUPT6H 抗体)-B cell markers
Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 (显示 TP53 抗体) in the kidney.
OCT2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
An association was found between SNPs in OCT2 transporter and lack of metformin response in type 2 diabetes mellitus patients.
Seventeen of the variants observed in the SLC22A2 gene of the Xhosa population were specific to/or occurred at a higher frequency in African populations or populations with a recent connection to the African continent.
We noted a statistically significant association between the nonsynonymous SNP rs316019(SLC22A2) and cisplatin-induced ototoxicity, in that the T allele occurred more frequently in patients who experienced no ototoxicity from cisplatin treatment.
the loss-of-function variant OCT2-T201M (rs145450955) contribute to changes in insulin (显示 INS 抗体) resistance and beta cell activity in patients with T2D treated with metformin.
The 808G>T variant of SLC22A2 improves the metformin long-term glucose-lowering effect in Chinese type 2 diabetics.
functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2
OCTN2 (显示 SLC22A5 抗体) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha (显示 PPARA 抗体).
Gene expression of the carnitine transporter OCTN2 (显示 SLC22A5 抗体) and carnitine transport are regulated by PPARbeta (显示 PPARD 抗体)/delta in bovine cells.
Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.
Data indicate that the expression of the organic cation transporters Slc22a1 (显示 SLC22A1 抗体), Slc22a2 and Slc22a3 (显示 OCT3 抗体) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (显示 TSC1 抗体)+/-renal tumours.
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.
Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
OCT1 (显示 POU2F1 抗体) and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (显示 PTPN2 抗体)) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP (显示 PTPN2 抗体) and MPTP (显示 PTPN2 抗体)-induced dopaminergic toxicity in rodents.
a comparison of the transport properties of Oct2 and Oct1 (显示 POU2F1 抗体)
This study shows that Oct1 (显示 POU2F1 抗体) and Oct2 together are essential for renal secretion of (small) organic cations.
The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
, POU domain, class 2, transcription factor 2
, lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
, octamer-binding protein 2
, octamer-binding transcription factor 2
, organic cation transporter 2
, solute carrier family 22 member 2
, apical organic cation transporter
, solute carrier family 22, member 2