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The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane.
rs2270641 SNP was associated with ASD (显示 ARSD ELISA试剂盒) risk only in over-dominant model. AA genotype of the rs1390938 was protective against ASD (显示 ARSD ELISA试剂盒) under dominant and recessive models.
Genetic variants in VMAT1 contribute to the severity of alcohol withdrawal in patients of European descent.
VMAT1 and VMAT2 (显示 Slc18a2 ELISA试剂盒) are expressed in the majority of neuroblastomas
SLC18A1 gene polymorphisms are associated with the risk of paranoid schizophrenia in Russians and Tatars.
The data of this study showed that VMAT1 polymorphisms influence monoamine signaling, the functional response of emotional brain circuits and risk for psychopathology.
Deletion of amino acids 307-338 in hVMAT1 isoform-b abolishes transport activity, and a 136-Thr (显示 TRH ELISA试剂盒) partially reduces activity of isoform-a.
we found a significant down-regulation of the gene coding for the vesicular monoamine transporter (显示 Slc18a2 ELISA试剂盒) (VMAT1)in enteroendocrine cells infected with Chlamydia trachomatis
Human bronchial arterial smooth muscle cells express OCT-1 (显示 POU2F1 ELISA试剂盒) and extraneuronal monoamine transporter(EMT). EMT (显示 ITK ELISA试剂盒) is the predominant plasma membrane transporter for norepinephrine uptake.
Greater expression of VMAT 1 in von Hippel-Lindau syndrome than multiple endocrine neoplasia type 2. Expression of VMAT 2 (显示 Slc18a2 ELISA试剂盒) did not differ significantly.
VMAT1Delta15 is not localized in large, dense core vesicles as the native form but in the endoplasmic reticulum. While VMAT1 can take up serotonin, VMAT1Delta15 cannot, indicating different functions for the two forms of VMAT1.
Study shows that VMAT1 is expressed in mouse brain and plays a key role in survival of hippocampal neurons
a functional VMAT-1 mRNA coding sequence is expressed in mouse brain and suggest processing of VMAT-1 protein differs in mouse adrenal and brain
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993
solute carrier family 18 (vesicular monoamine), member 1
, chromaffin granule amine transporter-like
, chromaffin granule amine transporter
, solute carrier family 18 member 1
, vesicular amine transporter 1
, solute carrier family 18, member 1
, solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)
, vesicular monoamine transporter 1