Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) ELISA试剂盒

SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. 再加上,我们可以发Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 抗体 (85)Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 蛋白 (11)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
SLC12A3 6559 P55017
大鼠 SLC12A3 SLC12A3 54300 P55018
小鼠 SLC12A3 SLC12A3 20497 P59158

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Human Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. Report novel SLC12A3 mutations in Chinese patients with Gitelman syndrome.

  2. we identified a novel SLC12A3 mutation in a Chinese GS pedigree, leading to the substitution of leucine by proline at codon 700 of the NCCT transporter. The proband and his elder sister had a homozygous mutation, while his mother and daughter carried one mutated allele. Because only the proband suffered from bilateral lower limb weakness, we inferred that the same genotype manifests as diverse phenotypes.

  3. MDCKI cells can be used to assess the activity, cellular localization, and abundance of wild-type or mutant NCC.

  4. In wild-type, total (tNCC (显示 TNNC1 ELISA试剂盒)) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC (显示 TNNC1 ELISA试剂盒) and pNCC increased significantly in males to levels not different from those in females.

  5. NCC1 (显示 CCL13 ELISA试剂盒)/2, NCC1 (显示 CCL13 ELISA试剂盒)-3, and pNCC1-3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in urinary extracellular vesicles of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.

  6. Data show that WNK lysine deficient protein kinase 3 (显示 WNK3 ELISA试剂盒) protein (WNK3 (显示 WNK3 ELISA试剂盒)) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.

  7. variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.

  8. A significant association of the SLC12A3 rs11643718 and ELMO1 (显示 ELMO1 ELISA试剂盒) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.

  9. This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.

  10. SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.

Mouse (Murine) Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. long-term aldosterone administration stimulates mouse NCC and pT58-NCC abundances in late distal convoluted kidney tubules.

  2. Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure.

  3. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (显示 WNK4 ELISA试剂盒)-SPAK (显示 STK39 ELISA试剂盒) signal pathway using WNK4 (显示 WNK4 ELISA试剂盒)-/- and SPAK (显示 STK39 ELISA试剂盒)-/- mice.

  4. The Role of Epithelial Sodium Channel ENaC (显示 SCNN1A ELISA试剂盒) and the Apical Cl-/HCO3- Exchanger Pendrin (显示 SLC26A4 ELISA试剂盒) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

  5. This study identifies NCC as an IL18 (显示 IL18 ELISA试剂盒)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.

  6. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (显示 LEPR ELISA试剂盒) mice from 6, 12, and 26 weeks at the age.

  7. SPAK (显示 STK39 ELISA试剂盒)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.

  8. NCC inhibition stimulates duodenal Ca(2 (显示 CA2 ELISA试剂盒)+) absorption as well as osteoblast differentiation and bone Ca(2 (显示 CA2 ELISA试剂盒)+) storage, possibly through a FAK (显示 PTK2 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒) dependent mechanism

  9. P2Y2 (显示 P2RY2 ELISA试剂盒)-mediated increase of cytoplasmic Ca(2 (显示 CA2 ELISA试剂盒)+) concentration down-regulates the expression of NCC.

  10. Estradiol, progesterone, and prolactin (显示 PRL ELISA试剂盒) increase renal NaCl cotransporter phosphorylation and activity.

Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) 抗原简介

Antigen Summary

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3) 抗体
  • thiazide-sensitive sodium chloride cotransporter (NCCT) 抗体
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 (slc12a3.2) 抗体
  • solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3) 抗体
  • solute carrier family 12 (sodium/chloride transporter), member 3 (Slc12a3) 抗体
  • solute carrier family 12, member 3 (Slc12a3) 抗体
  • AI035291 抗体
  • DKFZp469N2315 抗体
  • NCC 抗体
  • NCCT 抗体
  • slc12a3 抗体
  • TSC 抗体

Protein level used designations for SLC12A3

solute carrier family 12 (sodium/chloride transporters), member 3 , thiazide-sensitive sodium chloride cotransporter , solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 , solute carrier family 12 member 3-like , Na-Cl cotransporter , Na-Cl symporter , NaCl electroneutral thiazide-sensitive cotransporter , solute carrier family 12 member 3 , thiazide-sensitive Na-Cl cotransporter , thiazide-sensitive sodium-chloride cotransporter , solute carrier family 12, member 3 , sodium chloride cotransporter

GENE ID SPECIES
415692 Gallus gallus
454108 Pan troglodytes
703090 Macaca mulatta
100009348 Oryctolagus cuniculus
100038063 Xenopus (Silurana) tropicalis
100051953 Equus caballus
100172399 Pongo abelii
100409101 Callithrix jacchus
100468795 Ailuropoda melanoleuca
100015656 Monodelphis domestica
6559 Homo sapiens
54300 Rattus norvegicus
478118 Canis lupus familiaris
404171 Bos taurus
20497 Mus musculus
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