Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) ELISA试剂盒

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. 再加上,我们可以发Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 抗体 (115)Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
大鼠 SLC12A5 SLC12A5 171373 Q63633
SLC12A5 57468 Q9H2X9
小鼠 SLC12A5 SLC12A5 57138 Q91V14

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适于 Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 相互作用对的更多 ELISA 试剂盒

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) interaction partners

  1. Study shows that the overall expression of potassium-chloride cotransporter (显示 SLC12A7 ELISA试剂盒)-2 is increased in the hippocampi of temporal lobe epilepsy patients.

  2. Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut

  3. The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons.

  4. SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC (显示 CALR ELISA试剂盒).

  5. the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms.

  6. A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability.

  7. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (显示 WNK1 ELISA试剂盒)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  8. a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses.

  9. These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.

  10. KCC2-R952H from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) interaction partners

  1. Neonatal maternal separation leads to KCC2 expression inhibition persisting until adolescence in hippocampus.

  2. TGF-beta2 (显示 TGFB2 ELISA试剂盒) is a new regulatory factor for KCC2 functional activation and membrane trafficking.

  3. GABAA (显示 GABRg1 ELISA试剂盒) receptor (GABAAR (显示 GABRG2 ELISA试剂盒)) and the Na(+)-K(+)-2Cl(-) cotransporter (显示 SLC12A1 ELISA试剂盒) (NKCC1 (显示 SLC12A2 ELISA试剂盒)), but not the K(+)-Cl(-) cotransporter (显示 SLC12A4 ELISA试剂盒) (KCC2), were expressed in the terminals of the CRH (显示 CRH ELISA试剂盒) neurons at the median eminence (ME). In contrast, CRH (显示 CRH ELISA试剂盒) neuronal somata were enriched with KCC2 but not with NKCC1 (显示 SLC12A2 ELISA试剂盒).

  4. GluK2 (显示 GRIK2 ELISA试剂盒)-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).

  5. KCC2 expression supersedes NKCC1 (显示 SLC12A2 ELISA试剂盒) in mature fiber cells in mouse and rabbit lenses.

  6. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (显示 WNK1 ELISA试剂盒)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  7. Repeated stress decreased KCC2 expression and increased NKCC1 (显示 SLC12A2 ELISA试剂盒) expression in membranes of granular and pyramidal cells in the hippocampus.

  8. Decreasing [Cl(-)]i levels caused by increasing KCC2 levels in the 12 N could play important roles in regulating the frequency of respiration-related rhythmic activity during development.

  9. Results showed that the fast functional up-regulation of KCC2 in the mouse hippocampus following neonatal status epilepticus is dependent on BDNF (显示 BDNF ELISA试剂盒)

  10. In these neurons, the plasmalemmal expression of KCC2, which establishes the low [Cl(-) ]i required for GABAA R (显示 GABRG2 ELISA试剂盒)-mediated inhibition

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) 抗原简介

Antigen Summary

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with SLC12A5

  • solute carrier family 12 (potassium/chloride transporter), member 5 (SLC12A5) 抗体
  • solute carrier family 12 (potassium-chloride transporter), member 5 (Slc12a5) 抗体
  • solute carrier family 12, member 5 (Slc12a5) 抗体
  • KCC2 抗体
  • mKIAA1176 抗体

Protein level used designations for SLC12A5

solute carrier family 12 (potassium/chloride transporter), member 5 , K-Cl cotransporter 2 , electroneutral potassium-chloride cotransporter 2 , furosemide-sensitive K-Cl cotransporter , neuronal K-Cl cotransporter , neuronal-specific K-Cl cotransporter , rKCC2 , solute carrier family 12 member 5 , solute carrier family 12, member 5 , erythroid K-Cl cotransporter 2 , hKCC2 , mKCC2

GENE ID SPECIES
100155991 Sus scrofa
171373 Rattus norvegicus
57468 Homo sapiens
57138 Mus musculus
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