Use your antibodies-online credentials, if available.
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. 再加上，我们可以发Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 抗体 (115) 和 Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 蛋白 (8)和数多这个蛋白质的别的产品。
Showing 1 out of 1 products:
SLC12A5 promoted the migration and invasion of BUC by enhancing MMP-7 (显示 MMP7 ELISA试剂盒) expression.
Study shows that the overall expression of potassium-chloride cotransporter (显示 SLC12A7 ELISA试剂盒)-2 is increased in the hippocampi of temporal lobe epilepsy patients.
Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut
The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons.
SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC (显示 CALR ELISA试剂盒).
the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms.
A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability.
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (显示 WNK1 ELISA试剂盒)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses.
These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.
This study directly implicates the dephosphorylation and downregulation of KCC2 in the peritumoral brain region in the pathophysiology of tumor-associated epilepsy in disease model mice; proposes that glutamate (显示 GRIN1 ELISA试剂盒) release from glioma cells mediate the dephosphorylation and downregulation of KCC2, revealing yet another target for the treatment of tumor-associated epilepsies.
Study showed that there is a transient dysregulation in the levels of NKCC1 (显示 SLC12A2 ELISA试剂盒) and KCC2 at disease onset, the time point when heightened nociceptive behaviors are most pronounced in mice with experimental autoimmune encephalomyelitis.
Neonatal maternal separation leads to KCC2 expression inhibition persisting until adolescence in hippocampus.
TGF-beta2 (显示 TGFB2 ELISA试剂盒) is a new regulatory factor for KCC2 functional activation and membrane trafficking.
GABAA (显示 GABRg1 ELISA试剂盒) receptor (GABAAR (显示 GABRG2 ELISA试剂盒)) and the Na(+)-K(+)-2Cl(-) cotransporter (显示 SLC12A1 ELISA试剂盒) (NKCC1 (显示 SLC12A2 ELISA试剂盒)), but not the K(+)-Cl(-) cotransporter (显示 SLC12A4 ELISA试剂盒) (KCC2), were expressed in the terminals of the CRH (显示 CRH ELISA试剂盒) neurons at the median eminence (ME). In contrast, CRH (显示 CRH ELISA试剂盒) neuronal somata were enriched with KCC2 but not with NKCC1 (显示 SLC12A2 ELISA试剂盒).
GluK2 (显示 GRIK2 ELISA试剂盒)-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).
KCC2 expression supersedes NKCC1 (显示 SLC12A2 ELISA试剂盒) in mature fiber cells in mouse and rabbit lenses.
Repeated stress decreased KCC2 expression and increased NKCC1 (显示 SLC12A2 ELISA试剂盒) expression in membranes of granular and pyramidal cells in the hippocampus.
Decreasing [Cl(-)]i levels caused by increasing KCC2 levels in the 12 N could play important roles in regulating the frequency of respiration-related rhythmic activity during development.
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.
solute carrier family 12 (potassium/chloride transporter), member 5
, K-Cl cotransporter 2
, electroneutral potassium-chloride cotransporter 2
, furosemide-sensitive K-Cl cotransporter
, neuronal K-Cl cotransporter
, neuronal-specific K-Cl cotransporter
, solute carrier family 12 member 5
, solute carrier family 12, member 5
, erythroid K-Cl cotransporter 2