anti-Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) 抗体

SIGLEC1 encodes a member of the immunoglobulin superfamily. 再加上,我们可以发SIGLEC1 试剂盒 (25)SIGLEC1 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SIGLEC1 20612 Q62230
SIGLEC1 6614 Q9BZZ2
SIGLEC1 311426  

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Showing 10 out of 234 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 FACS, IHC (fro), IHC (p), in vitro, IHC, RIA, ELISA, WB Immunohistochemistry-Paraffin: Sialoadhesin Antibody (HSn 7D2) [ABIN153421] - IHC staining of Sialoadhesin in human spleen using DAB with hematoxylin counterstain. Flow Cytometry: Siglec-1/CD169 Antibody (HSn 7D2)  - Human CD14+ PBMC differentiated to M1 macrophages with rhGM-CSF were stained with Mouse Anti- Siglec-1/CD169 Monoclonal Antibody ( open histogram) followed by APC-conjugated Anti-Mouse IgG Secondary Antibody . 0.1 mL Log in to see 25至31个工作日
¥3,333.96
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小鼠 大鼠 FITC FACS 0.1 mg Log in to see 29至35个工作日
¥6,104.12
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小鼠 大鼠 非结合性 CyTOF, FACS, WB Detection of Siglec-1/CD169 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Mouse Siglec-1/CD169 Monoclonal Antibody. Detection of Mouse Siglec-1/CD169 by Western Blot. Western blot shows lysates of mouse splenocytes. PVDF Membrane was probed with 1 ug/mL of Mouse Siglec-1/CD169 Monoclonal Antibody. This experiment was conducted under non-reducing conditions. 100 μg Log in to see 26至31个工作日
¥2,144.03
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小鼠 大鼠 非结合性 FACS, IHC (fro), IF 0.1 mg Log in to see 29至35个工作日
¥4,691.64
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小鼠 大鼠 Biotin IHC (fro)   0.2 mg Log in to see 29至35个工作日
¥5,700.61
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小鼠 大鼠 PE FACS 100 Tests Log in to see 26至31个工作日
¥2,229.79
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小鼠 大鼠 非结合性 FACS, IHC (fro)   0.2 mg Log in to see 29至35个工作日
¥5,196.09
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小鼠 非结合性 CyTOF, FACS Detection of Siglec-1/CD169 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 20 ng/mL Recombinant Human IFN-gamma. Detection of Siglec-1/CD169 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 20 ng/mL Recombinant Human IFN-gamma. 100 μg Log in to see 26至31个工作日
¥2,272.67
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小鼠 大鼠 FITC FACS, IF   0.1 mg Log in to see 29至35个工作日
¥5,095.23
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Pig 小鼠 FITC FACS   0.1 mg Log in to see 29至35个工作日
¥5,700.61
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通过反应活性、应用领域、克隆类型和共轭标记 SIGLEC1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-SIGLEC1 抗体

  1. Human Monoclonal SIGLEC1 Primary Antibody for FACS, IHC (fro) - ABIN153421 : Hartnell, Steel, Turley, Jones, Jackson, Crocker: Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. in Blood 2001 (PubMed)
    Show all 10 Pubmed References

  2. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN2478776 : Kadir: Balloon occlusion technique for renal venography. in RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1979 (PubMed)
    Show all 4 Pubmed References

  3. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for IHC (fro), FACS - ABIN2478771 : Kaisho, Takeda, Tsujimura, Kawai, Nomura, Terada, Akira: IkappaB kinase alpha is essential for mature B cell development and function. in The Journal of experimental medicine 2001 (PubMed)
    Show all 4 Pubmed References

  4. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for IHC (fro), FACS - ABIN2478779 : Hughes, Schlichtenbrede, Murphy, Sarra, Luthert, Ali, Dick: Generation of activated sialoadhesin-positive microglia during retinal degeneration. in Investigative ophthalmology & visual science 2003 (PubMed)
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  5. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN2478775 : Schmied, Vetter, Nussberger, Siegenthaler: Production and characterisation of antisera to 18-hydroxy-11-deoxycorticosterone. in Steroids 1976 (PubMed)
    Show all 3 Pubmed References

  6. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for IHC (fro), FACS - ABIN2478774 : Alcamo, Hacohen, Schulte, Rennert, Hynes, Baltimore: Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. in The Journal of experimental medicine 2002 (PubMed)
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  7. Human Monoclonal SIGLEC1 Primary Antibody for Func, IHC (f) - ABIN2749112 : Kawasaki, Vela, Nycholat, Rademacher, Khurana, van Rooijen, Crocker, Kronenberg, Paulson: Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 2 Pubmed References

  8. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for CyTOF, FACS - ABIN4899472 : Honke, Shaabani, Merches, Gassa, Kraft, Ehrhardt, Häussinger, Löhning, Dittmer, Hengel, Recher, Lang, Lang: Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses. in European journal of immunology 2016 (PubMed)
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  9. Pig (Porcine) Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN2478767 : Mitchell: Recessive oncogenes, antioncogenes and tumour suppression. in British medical bulletin 1991 (PubMed)
    Show all 4 Pubmed References

更多抗SIGLEC1的相互作用对抗体

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. CD169(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (显示 CD8A 抗体)(+) T-cell exhaustion and immunopathology.

  2. Although CD169 participates in the immune response to tumour antigen and appears to be a positive prognostic marker for human cancers, its role in modulating melanoma growth and metastasis is less clear.

  3. Inhibition of Siglec-1 can prevent atherosclerotic lesion formation by suppress monocytes-endothelial cells adhesion and macrophages accumulation.

  4. Data show that knockdown of sialic acid binding Ig-like lectin 1 (siglec-1) in RAW 264.7 macrophage resulted in inhibiting the production of transforming growth factor beta 1 (TGF-beta1 (显示 TGFB1 抗体)) production.

  5. Viral infection significantly upregulated Siglec1 expression in mouse macrophages in an IFN/JAK (显示 JAK3 抗体)/STAT1 (显示 STAT1 抗体) pathway-dependent manner.

  6. Siglec-1 is a key receptor for macrophage/lymphocyte trans-infection of surface-bound virions, and the N-acyl side chain of sialic acid is a critical determinant for the Siglec-1/MLV interaction.

  7. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread.

  8. CD169(+) monocytes and macrophages have a critical role in preventing excessive inflammation in renal ischemia-reperfusion injury by downregulating intercellular adhesion molecule-1 (显示 ICAM1 抗体) expression on vascular endothelial cells.

  9. results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses

  10. Sialoadhesin is critical for macrophages to phagocytose and clear the sialylated pathogen group B Streptococcus.

Human Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid-binding immunoglobulin-like lectin.

  2. High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A (显示 TRIM21 抗体) indicates an enhanced risk for autoimmune congenital heart block development.

  3. These data demonstrate a prominent role for Siglec-1 in the internalization of HIV-1 to the virus-containing compartment in infected monocyte-derived macrophages

  4. These findings suggest that CD169+ macrophages in RLNs might be a useful marker for assessing clinical stage, including LN states, in patients with breast cancer.

  5. CD169 might act as a co-stimulatory molecule for cytotoxic T-cell activation, and could define a population of tumour-infiltrating macrophages with potential anti-tumour properties in human hepatocellular carcinoma tissues.

  6. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the lymph node sinus was a predictive factor for better clinical prognosis.

  7. Siglec-1 and Siglec-2 (显示 CD22 抗体) are potential biomarkers in autoimmune disease. (Review)

  8. Siglec-1 on myeloid cells could fuel novel CD4 (显示 CD4 抗体)(+) T-cell infections and contribute to HIV-1 dissemination in vivo.

  9. evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells

  10. Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses

Pig (Porcine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end.

  2. Fusion protein of sialoadhesin and domains 5-9 of CD163 (显示 CD163 抗体) receptors blocked the respiratory syndrome virus infection.

  3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin.

  4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology.

  5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently.

  6. ). These results provided fundamental evidence for CD163 (显示 CD163 抗体) and SN as two functional candidate genes affecting immunity in pigs.

  7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production

  8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.

  9. Sialoadhesin is confirmed as a PRRSV (porcine reproductive and respiratory syndrome virus)internalization receptor and is shown to interact with CD163 (显示 CD163 抗体) in PRRSV entry.

  10. Clear changes in the quantity of sialoadhesin(+) and CD163 (显示 CD163 抗体)(+) macrophages in the placentas and organs of embryos/fetuses during gestation.

SIGLEC1 抗原简介

蛋白简介

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound\; however, the full-length nature of this variant has not been determined.

Gene names and symbols associated with SIGLEC1

  • sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1) 抗体
  • sialoadhesin (LOC100345836) 抗体
  • sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1) 抗体
  • sialoadhesin (SIGLEC-1) 抗体
  • CD169 抗体
  • dJ1009E24.1 抗体
  • p210 抗体
  • pSn 抗体
  • SA 抗体
  • SIGLEC-1 抗体
  • SIGLEC1 抗体
  • SN 抗体

Protein level used designations for SIGLEC1

sialoadhesin , SER , sheep erythrocyte receptor , sialic acid-binding Ig-like lectin 1 , sialic acid-binding immunoglobulin-like lectin 1 , Sialic acid-binding Ig-like lectin 1

GENE ID SPECIES
469866 Pan troglodytes
100345836 Oryctolagus cuniculus
20612 Mus musculus
6614 Homo sapiens
311426 Rattus norvegicus
539759 Bos taurus
397623 Sus scrofa
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