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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. 再加上，我们可以发Sclerostin 抗体 (128) 和 Sclerostin 试剂盒 (63)和数多这个蛋白质的别的产品。
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observed an association between sclerostin levels with fasting insulin (显示 INS 蛋白) levels and homoeostatic model assessment-insulin (显示 INS 蛋白) resistance, but there was no clear association with type 2 diabetes risk.
Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (显示 EGFR 蛋白). Its involvement with other hormones of mineral homeostasis (FGF23 (显示 FGF23 蛋白)/Klotho (显示 KL 蛋白) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney
In chronic kidney disease, serum levels of the Wnt (显示 WNT2 蛋白) inhibitors DKK1 (显示 DKK1 蛋白) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (显示 DKK1 蛋白), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (显示 DPEP1 蛋白)), particularly in dialysis patients.
Vitamin D receptor (显示 VDR 蛋白) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.
SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.
Intermittent compressive stress regulates Notch (显示 NOTCH1 蛋白) receptor and target gene expression via the TGF-beta (显示 TGFB1 蛋白) signaling pathway. Notch (显示 NOTCH1 蛋白) signaling participates in TGF-beta (显示 TGFB1 蛋白)-induced sclerostin expression in periodontal ligament cells.
Dickkopf-1 (显示 DKK1 蛋白) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.
These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.
SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (显示 WNT2 蛋白)clerosis, possibly because of epigenetic silencing.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.
In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.
Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (显示 WNT2 蛋白) signaling pathway inhibition.
Analysis of SOST expression using large minigenes reveals the MEF2C (显示 MEF2C 蛋白) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (显示 TGFB1 蛋白) responsiveness.
removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting
chronic TNFalpha (tumor necrosis factor alpha (显示 TNF 蛋白))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.
Data show that the phenotype of Notch (显示 NOTCH1 蛋白) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (显示 DMP1 蛋白))-Cre;Rosa(Notch (显示 NOTCH1 蛋白)) mice hemizygous for the Dmp1 (显示 DMP1 蛋白)-sclerostin (SOST) transgene.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.