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SH3RF1 encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. 再加上，我们可以发SH3RF1 抗体 (42) 和 SH3RF1 蛋白 (4)和数多这个蛋白质的别的产品。
the active JNK (显示 MAPK8 ELISA试剂盒) signaling complex formed of POSH and the JNK (显示 MAPK8 ELISA试剂盒) module is essential for the expression of anterior neural genes and apoptosis in anterior development
These results show that POSH plays a critical role in the progression of epileptic seizures via N-methyl-D-aspartate receptor (显示 GRIN1 ELISA试剂盒) trafficking
Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein.
We found a genome-wide significant association for rs2282987 in CDK6 (显示 CDK6 ELISA试剂盒) and a consistent association for rs2706748 in SH3RF1 .
The data presented here define POSH and Siah2 (显示 SIAH2 ELISA试剂盒) as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy.
POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts
POSH disassociates from the JNK (显示 MAPK8 ELISA试剂盒) complex after phosphorylation of MLK3 (显示 MAP3K11 ELISA试剂盒) by Akt2 (显示 AKT2 ELISA试剂盒), which leads to down-regulation of the JNK (显示 MAPK8 ELISA试剂盒) signaling pathway
Results identified ALIX (显示 PDCD6IP ELISA试剂盒) as an ubiquitination substrate of POSH and indicate that POSH and ALIX (显示 PDCD6IP ELISA试剂盒) cooperate to facilitate efficient virus release.
POSH inhibits ROMK (显示 KCNJ1 ELISA试剂盒) channels by enhancing dynamin (显示 DNM1 ELISA试剂盒)-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK (显示 KCNJ1 ELISA试剂盒) channels.
this study shows that POSH is essential for the integration of cell-type-specific signals that regulate the differentiation, survival, and function of T cells
identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1 (显示 MAPK8IP1 ELISA试剂盒)) as a multiprotein scaffold network for TCR-mediated JNK1 (显示 MAPK8 ELISA试剂盒) activation in CD8 (显示 CD8A ELISA试剂盒)(+) T cells.
a mechanism by which POSH regulates the localization of activated Rac1 and F-actin assembly to control PCDLP formation and subsequent somal translocation of migratory neurons.
An intracellular signaling pathway for process outgrowth inhibition by Nogo66 implicates the POSH complex as a therapeutic target to enhance axon outgrowth and plasticity in the injured central nervous system.
Siah1 (显示 SIAH1 ELISA试剂盒) is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK (显示 MAPK8 ELISA试剂盒) pathway
POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP (显示 SMAD4 ELISA试剂盒) apoptotic complex), that includes all of the known kinase components of the pathway.
Results suggest that the molecular scaffold protein POSH assembles an inhibitory complex that links to the actin-myosin network to regulate neuronal process outgrowth.
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
SH3 multiple domains 2
, SH3 domain containing ring finger 1
, putative E3 ubiquitin-protein ligase SH3RF1
, plenty of SH3s
, SH3 domain-containing RING finger protein 1
, E3 ubiquitin-protein ligase SH3RF1
, SH3 multiple domains protein 2
, plenty of SH3 domains
, ring finger protein 142
, putative scaffolding protein POSH