Runt-Related Transcription Factor 1 (RUNX1) ELISA试剂盒

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上,我们可以发RUNX1 抗体 (279)RUNX1 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046

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适于 RUNX1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Leukaemogenesis by AML1-ETO (显示 RUNX1T1 ELISA试剂盒) requires enhanced C/D box snoRNA/RNP (显示 RNPC3 ELISA试剂盒) formation.

  2. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 ELISA试剂盒)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R ELISA试剂盒)), in Runx1/Cbfb (显示 CBFB ELISA试剂盒)-deleted MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells. Similar to the effect of Runx1/Cbfb (显示 CBFB ELISA试剂盒) deletion, PAR-1 (显示 MARK2 ELISA试剂盒) overexpression induced CDKN1A/p21 (显示 CDKN1A ELISA试剂盒) expression and attenuated proliferation in MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells

  3. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  4. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  5. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (显示 TLR4 ELISA试剂盒) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway.

  6. both repressor and activator functions of Runx1 at multiple hematopoietic stages and lineages likely contribute to the tumor suppressor activity in MDS (显示 MECOM ELISA试剂盒) and AML.

  7. Knock-down of PLC-gamma-1 (显示 PLCG1 ELISA试剂盒) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (显示 PLCG1 ELISA试剂盒)-transfected cells strongly inhibited foreign body giant cell formation.

  8. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1 (显示 HNF1A ELISA试剂盒), GATA-3 (显示 GATA3 ELISA试剂盒) and Runx1) activate Bcl11b (显示 BCL11B ELISA试剂盒) for T cell commitment

  9. Inhibition of Runx1 in multipotential myeloid precursor cells is important for osteoclast formation and function.

  10. Silencing of Runx1 attenuated the LPS (显示 TLR4 ELISA试剂盒)-induced IL-1beta (显示 IL1B ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒) production levels, but the TNF-alpha (显示 TNF ELISA试剂盒) levels were not affected. Overexpression of RUNX1 promoted IL-1beta (显示 IL1B ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒) production in response to LPS (显示 TLR4 ELISA试剂盒) stimulation.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Leukaemogenesis by AML1-ETO (显示 RUNX1T1 ELISA试剂盒) requires enhanced C/D box snoRNA/RNP (显示 RNPC3 ELISA试剂盒) formation.

  2. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 ELISA试剂盒)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R ELISA试剂盒)), in Runx1/Cbfb (显示 CBFB ELISA试剂盒)-deleted MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells. Similar to the effect of Runx1/Cbfb (显示 CBFB ELISA试剂盒) deletion, PAR-1 (显示 MARK2 ELISA试剂盒) overexpression induced CDKN1A/p21 (显示 CDKN1A ELISA试剂盒) expression and attenuated proliferation in MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells

  3. LRG1 (显示 LRG1 ELISA试剂盒) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (显示 CALR ELISA试剂盒)) by regulating RUNX1 expression.

  4. RUNX1 RNA and protein are upregulated in proliferative diabetic retinopathy and in response to high glucose in vitro. Immunohistochemical staining for RUNX1 showed reactivity in vessels of patient-derived fibrovascular membranes, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  5. RUNX1 overexpression induced partial DNA demethylation at SPI1 (显示 SPI1 ELISA试剂盒) proximal promoter.

  6. mutations in the SRSF2 (显示 SRSF2 ELISA试剂盒)/ASXL1 (显示 ASXL1 ELISA试剂盒)/RUNX1 gene panel identified as significant prognostic markers in systemic mastocytosis

  7. HHEX (显示 HHEX ELISA试剂盒) could replace RUNX1 in cooperating with FLT3 (显示 FLT3 ELISA试剂盒)-ITD to induce Acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML).

  8. RUNX1-mutated AML is associated with a complex mutation cluster and is correlated with distinct clinico-pathologic features and inferior prognosis.

  9. It was found that the absence of mutations in the SRSF2 (显示 SRSF2 ELISA试剂盒), ASXL1 (显示 ASXL1 ELISA试剂盒), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  10. Our findings suggest ETV6 (显示 ETV6 ELISA试剂盒)-RUNX1 is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (显示 RAB1A ELISA试剂盒) in early life leading to clinical leukemia.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (显示 CTCF ELISA试剂盒) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (显示 MYEF2 ELISA试剂盒) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (显示 RAD21 ELISA试剂盒), or cohesin subunit Smc3 (显示 SMC3 ELISA试剂盒), fail to express runx3 (显示 RUNX3 ELISA试剂盒) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (显示 RUNX2 ELISA试剂盒) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 抗原简介

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1) 抗体
  • runt-related transcription factor (runt) 抗体
  • runt related transcription factor 1 (Runx1) 抗体
  • runt-related transcription factor 1 (runx1) 抗体
  • runt-related transcription factor 1 (Runx1) 抗体
  • AI462102 抗体
  • aml 抗体
  • aml-1 抗体
  • Aml1 抗体
  • aml1-evi-1 抗体
  • amlcr1 抗体
  • cbfa2 抗体
  • evi-1 抗体
  • Pebp2a2 抗体
  • pebp2ab 抗体
  • Pebpa2b 抗体
  • Runx-1 抗体
  • runx1 抗体
  • runxa 抗体
  • XAML 抗体
  • Xaml1 抗体

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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