Runt-Related Transcription Factor 1 (RUNX1) ELISA试剂盒

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上,我们可以发RUNX1 抗体 (285)RUNX1 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (显示 AQP5 ELISA试剂盒) protein of the acinar cells in the SMG (显示 SNRPG ELISA试剂盒) in order to allow for the proper secretion of saliva (显示 RAG1AP1 ELISA试剂盒)

  2. High RUNX1 expression is associated with skin squamous cell carcinoma.

  3. deficiency alters the expression of a crucial subset of TAL1 (显示 TAL1 ELISA试剂盒)- and NOTCH1 (显示 NOTCH1 ELISA试剂盒)-regulated genes, including the MYB (显示 MYB ELISA试剂盒) and MYC (显示 MYC ELISA试剂盒) oncogenes, respectively.

  4. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  5. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  6. Leukaemogenesis by AML1-ETO (显示 RUNX1T1 ELISA试剂盒) requires enhanced C/D box snoRNA/RNP (显示 RNPC3 ELISA试剂盒) formation.

  7. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 ELISA试剂盒)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R ELISA试剂盒)), in Runx1/Cbfb (显示 CBFB ELISA试剂盒)-deleted MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells. Similar to the effect of Runx1/Cbfb (显示 CBFB ELISA试剂盒) deletion, PAR-1 (显示 MARK2 ELISA试剂盒) overexpression induced CDKN1A/p21 (显示 CDKN1A ELISA试剂盒) expression and attenuated proliferation in MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) cells

  8. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  9. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  10. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (显示 TLR4 ELISA试剂盒) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. discussion of the role of RUNX1 in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 expression

  3. deficiency alters the expression of a crucial subset of TAL1 (显示 TAL1 ELISA试剂盒)- and NOTCH1 (显示 NOTCH1 ELISA试剂盒)-regulated genes, including the MYB (显示 MYB ELISA试剂盒) and MYC (显示 MYC ELISA试剂盒) oncogenes, respectively.

  4. Our findings strengthen previous data concerning RUNX1 mutations in acute myeloid leukemia (显示 BCL11A ELISA试剂盒) and support the notion that RUNX1 mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

  5. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  6. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  7. The E3 ubiquitin ligase STUB1 (显示 STUB1 ELISA试剂盒) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (显示 RUNX1T1 ELISA试剂盒). Activation of STUB1 (显示 STUB1 ELISA试剂盒) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (显示 RUNX1T1 ELISA试剂盒) leukemia.

  8. The clinical significance of ETV6 (显示 ETV6 ELISA试剂盒)-RUNX1.

  9. Deliver the necessary promotional drive for the progression of ETV6 (显示 ETV6 ELISA试剂盒)-RUNX1+ pre-leukaemic cells.

  10. High RUNX1 expression is associated with pancreatic cancer.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (显示 CTCF ELISA试剂盒) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (显示 MYEF2 ELISA试剂盒) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (显示 RAD21 ELISA试剂盒), or cohesin subunit Smc3 (显示 SMC3 ELISA试剂盒), fail to express runx3 (显示 RUNX3 ELISA试剂盒) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (显示 RUNX2 ELISA试剂盒) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 抗原简介

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) 抗体
  • runt-related transcription factor (runt) 抗体
  • runt related transcription factor 1 (Runx1) 抗体
  • runt related transcription factor 1 (RUNX1) 抗体
  • runt-related transcription factor 1 (runx1) 抗体
  • runt related transcription factor 1 L homeolog (runx1.L) 抗体
  • runt-related transcription factor 1 (RUNX1) 抗体
  • runt-related transcription factor 1 (Runx1) 抗体
  • AI462102 抗体
  • aml 抗体
  • aml-1 抗体
  • Aml1 抗体
  • aml1-evi-1 抗体
  • amlcr1 抗体
  • cbfa2 抗体
  • evi-1 抗体
  • Pebp2a2 抗体
  • pebp2ab 抗体
  • Pebpa2b 抗体
  • Runx-1 抗体
  • runx1 抗体
  • runxa 抗体
  • XAML 抗体
  • Xaml1 抗体

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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