Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) 蛋白 (RUNX1T1)

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. 再加上,我们可以发RUNX1T1 抗体 (39)RUNX1T1 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
大鼠 RUNX1T1 RUNX1T1 362489  

antibodies-online.cn销售最多的RUNX1T1 蛋白

Showing 4 out of 6 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
¥195,007.14
详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
¥195,007.14
详细
HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
¥6,414.92
详细
小麦胚 GST tag 10 μg Log in to see 29至34个工作日
¥2,963.90
详细

RUNX1T1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1)互动伙伴

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Leukaemogenesis by AML1 (显示 RUNX1 蛋白)-ETO requires enhanced C/D box snoRNA/RNP (显示 RNPC3 蛋白) formation.

  2. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (显示 RUNX1 蛋白)-175) of AML1 (显示 RUNX1 蛋白)-ETO is consistent with its contribution to the activity of full-length AML1 (显示 RUNX1 蛋白)-ETO and is mediated through its direct association with the DNA-binding domain

  3. the AML1 (显示 RUNX1 蛋白)-ETO fusion protein increases the expression of SIRT1 (显示 SIRT1 蛋白), possibly by binding to the promoter region of SIRT1 (显示 SIRT1 蛋白) to activate its transcription in t(8;21) AML (显示 RUNX1 蛋白).

  4. A feedback circuitry involving miR (显示 MLXIP 蛋白)-9-1 and RUNX1 (显示 RUNX1 蛋白)-RUNX1T1.

  5. The role of RUNX1T1 in t(8;21) acute myeloid leukemia (显示 BCL11A 蛋白) and miRNA expression regulation

  6. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  7. Exon splicing patterns in the human RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 fusion gene present in acute myeloid leukemia (显示 BCL11A 蛋白) patients have been decoded.

  8. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (显示 RUNX1 蛋白)-ETO/RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 is facilitated by interaction with the chaperonin (显示 HSPD1 蛋白) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (显示 HSP70 蛋白)).

  9. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  10. A substantial fraction of AML1 (显示 RUNX1 蛋白)-ETO/p300 (显示 EP300 蛋白) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Leukaemogenesis by AML1 (显示 RUNX1 蛋白)-ETO requires enhanced C/D box snoRNA/RNP (显示 RNPC3 蛋白) formation.

  2. Data show that RUNX1 (显示 RUNX1 蛋白)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (显示 BCL11A 蛋白) (AML (显示 RUNX1 蛋白)) in a fraction (51%) of reconstituted mice.

  3. Self-renewal induced by AML1 (显示 RUNX1 蛋白)/ETO in primary murine progenitors was inhibited when Aes (显示 AES 蛋白) was decreased or absent.

  4. AML1 (显示 RUNX1 蛋白)-ETO synergizes with an ICSBP (显示 IRF8 蛋白) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  5. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (显示 CEBPB 蛋白) and a novel regulator of early adipogenesis

  6. the loss of the molecular events of AML1 (显示 RUNX1 蛋白)-ETO C-terminal NCoR (显示 NCOR1 蛋白)/SMRT-interacting domain transforms AML1 (显示 RUNX1 蛋白)-ETO into a potent leukemogenic protein

  7. p15(Ink4b (显示 CDKN2B 蛋白)) loss must be accompanied by additional oncogenic changes for RUNX1 (显示 RUNX1 蛋白)-ETO-associated AML (显示 RUNX1 蛋白) to develop

  8. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  9. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (显示 RUNX1 蛋白)-ETO

蛋白简介RUNX1T1

蛋白简介

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1)
  • AML1T1 蛋白
  • Cbfa2t1 蛋白
  • Cbfa2t1h 蛋白
  • CDR 蛋白
  • ETO 蛋白
  • MTG8 蛋白
  • si:ch211-232j17.1 蛋白
  • wu:fi14b07 蛋白
  • zgc:154044 蛋白
  • ZMYND2 蛋白

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
RUNX1T1 蛋白 (RUNX1T1) 精选生产商
您还需要查找其他产品吗?