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RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. 再加上，我们可以发RUNX1T1 抗体 (39) 和 RUNX1T1 试剂盒 (2)和数多这个蛋白质的别的产品。
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RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
Leukaemogenesis by AML1 (显示 RUNX1 蛋白)-ETO requires enhanced C/D box snoRNA/RNP (显示 RNPC3 蛋白) formation.
Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (显示 RUNX1 蛋白)-175) of AML1 (显示 RUNX1 蛋白)-ETO is consistent with its contribution to the activity of full-length AML1 (显示 RUNX1 蛋白)-ETO and is mediated through its direct association with the DNA-binding domain
the AML1 (显示 RUNX1 蛋白)-ETO fusion protein increases the expression of SIRT1 (显示 SIRT1 蛋白), possibly by binding to the promoter region of SIRT1 (显示 SIRT1 蛋白) to activate its transcription in t(8;21) AML (显示 RUNX1 蛋白).
A feedback circuitry involving miR (显示 MLXIP 蛋白)-9-1 and RUNX1 (显示 RUNX1 蛋白)-RUNX1T1.
The role of RUNX1T1 in t(8;21) acute myeloid leukemia (显示 BCL11A 蛋白) and miRNA expression regulation
Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance
Exon splicing patterns in the human RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 fusion gene present in acute myeloid leukemia (显示 BCL11A 蛋白) patients have been decoded.
Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (显示 RUNX1 蛋白)-ETO/RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 is facilitated by interaction with the chaperonin (显示 HSPD1 蛋白) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (显示 HSP70 蛋白)).
AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.
Data show that RUNX1 (显示 RUNX1 蛋白)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (显示 BCL11A 蛋白) (AML (显示 RUNX1 蛋白)) in a fraction (51%) of reconstituted mice.
Self-renewal induced by AML1 (显示 RUNX1 蛋白)/ETO in primary murine progenitors was inhibited when Aes (显示 AES 蛋白) was decreased or absent.
AML1 (显示 RUNX1 蛋白)-ETO synergizes with an ICSBP (显示 IRF8 蛋白) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia
molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (显示 CEBPB 蛋白) and a novel regulator of early adipogenesis
the loss of the molecular events of AML1 (显示 RUNX1 蛋白)-ETO C-terminal NCoR (显示 NCOR1 蛋白)/SMRT-interacting domain transforms AML1 (显示 RUNX1 蛋白)-ETO into a potent leukemogenic protein
p15(Ink4b (显示 CDKN2B 蛋白)) loss must be accompanied by additional oncogenic changes for RUNX1 (显示 RUNX1 蛋白)-ETO-associated AML (显示 RUNX1 蛋白) to develop
AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a
the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (显示 RUNX1 蛋白)-ETO
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
, expressed during postmitotic spinal neurons, most likely in motorneurons
, acute myelogenous leukemia 1 translocation 1, cyclin-D related
, core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related
, eight twenty one protein
, myeloid translocation gene on 8q22
, zinc finger MYND domain-containing protein 2
, CBFA2T1 identified gene homolog
, acute myelogenous leukemia 1 translocation 1 protein
, core-binding factor, runt domain, alpha subunit 2
, cyclin D-related
, translocated to, 1