anti-Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) 抗体

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. 再加上,我们可以发ROBO4 试剂盒 (8)ROBO4 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ROBO4 54538 Q8WZ75
ROBO4 74144 Q8C310
ROBO4 300518 Q80W87
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Showing 10 out of 152 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 CyTOF, FACS, WB Detection of ROBO4 in HUVEC Human Cells by Flow Cytometry. Human umbilical vein endothelial cells were stained with Mouse Anti-Human ROBO4 Monoclonal Antibody. Detection of ROBO4 in HUVEC Human Cells by Flow Cytometry. Human umbilical vein endothelial cells were stained with Mouse Anti-Human ROBO4 Monoclonal Antibody. 100 μg Log in to see 8至9个工作日
$262.50
详细
小鼠 PE FACS Detection of ROBO4 in Human ROBO4 Transfectants by Flow Cytometry. Human ROBO4 transfectants were stained with Mouse Anti-Human ROBO4 PE-conjugated Monoclonal Antibody. Detection of ROBO4 in Human ROBO4 Transfectants by Flow Cytometry. Human ROBO4 transfectants were stained with Mouse Anti-Human ROBO4 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8至9个工作日
$320.25
详细
非结合性 IF (p), IHC (p), WB Mouse intestine cells probed with Rabbit Anti-Robo4 Polyclonal Antibody, FITC Conjugated (ABIN714866-FITC) (green) at 1:50 for 60 minutes compared to control cells (red). Rat brain lysate probed with Anti Robo4 Polyclonal Antibody, Unconjugated  at 1:3000 for 90 min at 37˚C. Predicted band 108kD. Observed band size: 171kD 100 μL Log in to see 3至7个工作日
$295.90
详细
非结合性 WB 100 μg Log in to see 2至3个工作日
$265.00
详细
山羊 Biotin FACS, WB   50 μg Log in to see 8至9个工作日
$399.00
详细
非结合性 ELISA   100 μg Log in to see 20至21个工作日
$218.90
详细
非结合性 IHC (p), IHC, WB Detection of ROBO4 in HUVEC lysate using ABIN189709. Detection of ROBO4 in endothelium and trophoblasts of the placenta using ABIN189709. 0.1 mL Log in to see 7至9个工作日
$381.94
详细
非结合性 IHC (p), IHC, WB Detection of ROBO4 in HUVEC lysate using ABIN189711. Detection of ROBO4 in human placental epithelial cells and trophoblasts using ABIN189711. 0.1 mL Log in to see 7至9个工作日
$381.94
详细
Alexa Fluor 594 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Cy5.5 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 ROBO4 抗体

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引用最多的anti-ROBO4 抗体

  1. Human Monoclonal ROBO4 Primary Antibody for CyTOF, FACS - ABIN4900078 : Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal ROBO4 Primary Antibody for FACS, WB - ABIN4900077 : Zhang, Prahst, Mathivet, Pibouin-Fragner, Zhang, Genet, Tong, Dubrac, Eichmann: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. in Nature communications 2016 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal ROBO4 Primary Antibody for FACS - ABIN4897148 : Zhang, Fisher, Newey, Smythe, Tatton, Tsaknakis, Forde, Carpenter, Athanassopoulos, Hale, Ferguson, Tyler, Watt: The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. in Stem cells and development 2009 (PubMed)

更多抗ROBO4的相互作用对抗体

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Sox7 (显示 SOX7 抗体) and Sox18 (显示 SOX18 抗体)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature

  2. robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.

  3. Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.

  2. Robo4 vaccines induce antibodies that retard tumor growth.

  3. Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.

  4. These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.

  5. our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms

  6. Data found that expression of Slit2 (显示 SLIT2 抗体) and SDF1 (显示 CXCL12 抗体) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.

  7. augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis

  8. Robo4 specifically binds to UNC5B (显示 UNC5B 抗体), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  9. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.

  10. enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.

Human Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (显示 SP1 抗体) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (显示 PSG1 抗体)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.

  2. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy

  3. These results suggest that Slit2 (显示 SLIT3 抗体)/Robo1 (显示 ROBO1 抗体) binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 (显示 ROBO1 抗体) may function by interacting with CdGAP (显示 ARHGAP31 抗体) in HUVECs.

  4. results indicate that AP-1 (显示 FOSB 抗体) complexes regulate Robo4 gene expression in endothelial cells

  5. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (显示 RUNX1 抗体) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.

  6. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and FAK (显示 PTK2 抗体) signaling pathways.

  7. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (显示 HIF1A 抗体) suggesting that Robo4 is positively regulated by HIF-1alpha (显示 HIF1A 抗体) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.

  8. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (显示 CPB1 抗体)

  9. This study demonistrated that roundabout (显示 ROBO1 抗体) 4 regulates blood-tumor barrier permeability through the modulation of ZO-1 (显示 TJP1 抗体), Occludin (显示 OCLN 抗体), and Claudin-5 (显示 CLDN5 抗体) expression.

  10. Endothelial cell-specific DNA methylation (显示 HELLS 抗体) pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.

ROBO4 抗原简介

蛋白简介

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene names and symbols associated with ROBO4

  • roundabout guidance receptor 4 (ROBO4) 抗体
  • roundabout guidance receptor 4 (Robo4) 抗体
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (robo4) 抗体
  • 1200012D01Rik 抗体
  • AI593217 抗体
  • ECSM4 抗体
  • MRB 抗体
  • sc:d0823 抗体
  • wu:fa16f09 抗体

Protein level used designations for ROBO4

roundabout homolog 4 , roundabout homolog 4, magic roundabout , Magic roundabout , magic roundabout

GENE ID SPECIES
54538 Homo sapiens
74144 Mus musculus
300518 Rattus norvegicus
560765 Danio rerio
489306 Canis lupus familiaris
100524821 Sus scrofa
783785 Bos taurus
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