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Putative signaling adapter which may play a role in neuronal differentiation. 再加上，我们可以发RUN and SH3 Domain Containing 1 蛋白 (4)和数多这个蛋白质的别的产品。
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RUN domain of NESCA can bind H-Ras (显示 HRAS 抗体), a downstream signaling molecule of TrkA (显示 NTRK1 抗体), with high affinity. Moreover, NESCA RUN can directly interact with TrkA (显示 NTRK1 抗体).
Nesca functions as an adapter involved in neuronal vesicular transport
Data show that NESCA and NEMO (显示 IKBKG 抗体) interact by their N-terminal region, that NESCA directly associates with TRAF6 (显示 TRAF6 抗体), which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6 (显示 TRAF6 抗体)-mediated polyubiquitination of NEMO (显示 IKBKG 抗体).
Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin (显示 BDNF 抗体)-dependent neurite outgrowth.
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (By similarity).
RUN and SH3 domain containing 1
, RUN and SH3 domain-containing protein 1
, new molecule containing SH3 at the carboxy-terminus