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RAB1A encodes a member of the Ras superfamily of GTPases. 再加上，我们可以发RAB1A 抗体 (43) 和 RAB1A 蛋白 (14)和数多这个蛋白质的别的产品。
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The authors demonstrate in zebrafish that nf1 (显示 NF1 ELISA试剂盒) loss leads to aberrant activation of RAS signaling in MYCN (显示 MYCN ELISA试剂盒)-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (显示 ARHGEF16 ELISA试剂盒) in nf1 (显示 NF1 ELISA试剂盒)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (显示 NF1 ELISA试剂盒) mutant embryos.
Ras activity levels control the repopulation and expansion of adult melanocyte precursors after tissue loss, enabling the recovery of patterned melanocyte stripes during zebrafish appendage regeneration.
Drosophila Tempura, a novel protein prenyltransferase alpha subunit, regulates notch signaling via Rab1 and Rab11.
Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway.
Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP
These data indicate that AMPylation of Rab1 is an effective strategy to maintain this GTPase (显示 RACGAP1 ELISA试剂盒) on the Legionella-containing vacuole membrane.
Rab1A is the first crucial component of the anterograde melanosome transport machinery to be identified in mammalian skin melanocytes.
Acute expression of Rab1 and Rab3d (显示 RAB3D ELISA试剂盒) DN constructs partially alleviated this negative feedback mechanism and resulted in impaired ER to Golgi trafficking of procollagen.
Legionella pneumophila SidD catalyzed AMP (显示 TMPRSS5 ELISA试剂盒) release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB; identified SidD as missing link connecting processes of early Rab1 accumulation and subsequent removal during infection
Rab1 and Rab6 GTPases may play a role in modulating the function of retina by mediating the transport of nascent proteins along the early secretary pathway, particularly in the process of the light adaptation.
Data show Trs130 (显示 TRAPPC9 ELISA试剂盒) (mTrs130) is a component of an analogous TRAPP complex that this complex is enriched on COPI (Coat Protein (显示 GOLPH3 ELISA试剂盒) I (显示 ANXA2 ELISA试剂盒))-coated vesicles it specifically activates Rab1.
elevated expression of Rab1 protected against alpha-Synuclein (显示 SNCA PLURAL_@19416@)-induced dopaminergic neuron loss in animal models of Parkinson Disease
Rab1A may be involved in the pathogenesis of human lung cancer in an mTOR (显示 FRAP1 ELISA试剂盒)- and MAPK (显示 MAPK1 ELISA试剂盒)-independent manner.
In clinical samples, the expression of Rab1A or DHX33 (显示 DHX33 ELISA试剂盒) was reversely correlated with miR (显示 MLXIP ELISA试剂盒)-634. Re-expression of Rab1A or DHX33 (显示 DHX33 ELISA试剂盒) abrogated the miR (显示 MLXIP ELISA试剂盒)-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR (显示 MLXIP ELISA试剂盒)-634 in hepatocellular carcinoma.
New Rab1 binding sites have been discovered using an ensemble of clustering methods.
Leucine-rich repeat kinase 2 (LRRK2 (显示 LRRK2 ELISA试剂盒)) can interact with several Rab (显示 HRB ELISA试剂盒) proteins, and such ractions may serve to recruit LRRK2 (显示 LRRK2 ELISA试剂盒) to distinct subcellular organelles to phosphorylate select substrate proteins involved in membrane trafficking events.
As a Rab1a effector, C9orf72 controls initiation of autophagy by regulating the Rab1a-dependent trafficking of the ULK1 (显示 ULK1 ELISA试剂盒) autophagy initiation complex to the phagophore.
our data indicate that miR (显示 MLXIP ELISA试剂盒)-1202 suppresses proliferation and induces endoplasmic reticulum stress and apoptosis through targeting and inhibiting Rab1A in glioma cells. These results suggest miR (显示 MLXIP ELISA试剂盒)-1202 as a potential therapeutic target for the treatment of glioma patients.
Upregulation of RAB1A is associated with triple-negative breast cancer.
For RAB1A, a high accuracy for the discrimination of human hepatocellular carcinoma and nontumorous liver tissue was observed.
The ability of Rab1 to regulate WHAMM and the Arp2/3 complex represents a distinct strategy for membrane remodeling in which a Rab G-protein recruits the actin nucleation machinery but dampens its activity.
Rab1A isoform 3 shows enhanced basal activity and is not controlled by accessory proteins
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms.
ras-related protein Rab-1A
, RAB1A, member RAS oncogene family
, RAB1, member RAS oncogene family
, Rab-protein 1
, dendritic arbor reduction 6
, rab1A protein
, hypothetical protein
, YPT1-related protein
, ras-related YPT1 protein
, GTP binding protein Rab1a
, Rab GTPase YPT1 homolog
, RAB1B, member RAS oncogene family