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PDHX ELISA试剂盒

(Pyruvate Dehydrogenase Complex, Component X (PDHX))
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
PDHX ELISA 试剂盒 PDHX ELISA 试剂盒 PDHX ELISA 试剂盒 (ABIN6959008)

PDHX 适用: 人 Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Cell Lysate, Tissue Homogenate

PDHX ELISA 试剂盒 (ABIN423044)

PDHX 适用: 人 Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Plasma, Serum

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Popular PDHX ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959008
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Sandwich ELISA
Validations
Cat. No. ABIN423044
Quantity 96 tests
Datasheet Datasheet

Aliases for PDHX ELISA试剂盒

pyruvate dehydrogenase complex component X (PDHX) ELISA试剂盒
pyruvate dehydrogenase complex, component X (Pdhx) ELISA试剂盒
pyruvate dehydrogenase complex, component X (pdhx) ELISA试剂盒
pyruvate dehydrogenase complex component X L homeolog (pdhx.L) ELISA试剂盒
E3-binding protein (pdhX) ELISA试剂盒
pyruvate dehydrogenase complex component X (pdhx) ELISA试剂盒
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