Protein Quaking 蛋白 (QKI)

The protein encoded by QKI is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. 再加上,我们可以发QKI 抗体 (94)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
QKI 9444 Q96PU8
QKI 19317 Q9QYS9
QKI 499022  

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
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QKI 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

更多Protein Quaking (QKI)互动伙伴

Human Protein Quaking (QKI) interaction partners

  1. several splicing variants with functional relevance in lung cancer largely regulated by the splicing factor (显示 SLU7 蛋白) QKI, were identified.

  2. QKI underexpression is associated with glioma.

  3. Our results demonstrate that miR (显示 MLXIP 蛋白)-143-3p acts as a tumor-suppressor by targeting QKI-5 in ESCC, suggesting that miR (显示 MLXIP 蛋白)-143-3p is a potential therapy for the treatment of ESCC.

  4. Methylation of the QKI promoter and concomitant reduced expression of QKI mRNA may be important for CRC (显示 CALR 蛋白) initiation and progression.

  5. quaking is essential in maintaining endothelial barrier function.

  6. QKI-7 recruits PAPD4 (显示 PAPD4 蛋白) to regulate post-transcriptional polyadenylation of target mRNAs.

  7. QKI has a role in posttranscriptionally guiding macrophage identity and function.

  8. MYB (显示 MYB 蛋白)-QKI rearrangements promote tumorigenesis through three mechanisms: MYB (显示 MYB 蛋白) activation by truncation, enhancer translocation driving aberrant MYB (显示 MYB 蛋白)-QKI expression and hemizygous loss of the tumor suppressor QKI

  9. Data implicate QKI in the pathophysiology of inflammation and leukemoogenesis where miR (显示 MLXIP 蛋白)-155 is involved.

  10. miR (显示 MLXIP 蛋白)-155 regulates the cell cycle and invasion ability of colon cancer cells via the modulation of QKI expression

Cow (Bovine) Protein Quaking (QKI) interaction partners

  1. Complementary DNA (cDNA) for bovine quaking gene (Bqk), equine quaking gene (Eqk) and porcine quaking gene (Pqk), which are homologous to mouse quaking gene (qkI), were isolated, and their nucleotide sequences were determined.

Pig (Porcine) Protein Quaking (QKI) interaction partners

  1. miR (显示 MYLIP 蛋白)-499 was negatively correlated to the expression of QKI in testicular tissue.

Mouse (Murine) Protein Quaking (QKI) interaction partners

  1. QKI is involved in multiple aspects of oligodendroglial development. QKI disruption can impact the cell fate of oligodendrocyte precursor cells, their migration and differentiation, and ultimately myelination in the cerebellum.

  2. Data indicate a central role of microRNA miR-214 in embryonic stem cells (ESCs) - vascular smooth muscle cells (VSMCs) differentiation, and identified quaking (QKI) as a functional modulating target in miR-214 mediated VSMCs differentiation.

  3. QKI was strongly expressed by Muller glial cells in both the developing and adult retina. Neuronal expression was uniformly weak in the adult. QKI-5 was the predominantly expressed isoform in the adult retina.

  4. QKI directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 (显示 SIRT2 蛋白) to facilitate oligodendrocyte differentiation.

  5. findings reveal a crucial role for the miR (显示 MLXIP 蛋白)-214-Qki pathway in the regulation of neuronal dendritic development.

  6. we identify QKI as the long-sought regulator of Neurofascin (显示 NFASC 蛋白) alternative splicing

  7. Data implicate QKI in the pathophysiology of inflammation and leukemoogenesis where miR (显示 MLXIP 蛋白)-155 is involved.

  8. Study establish that the shk mutation, previously localized to chromosome 17, is a quaking (qk) allele consisting of a 105-nucleotide insertion in the qk regulatory region that decreases qk transcription

  9. These results suggested that QKI5 deficiency contributed to the overactivation of FoxO1 (显示 FOXO1 蛋白) in ob/ob animals and subsequently magnified nitrosative stress and endoplasmic reticulum stress.

  10. The study provides evidence that cytoplasmic quaking I-6 acts upstream of hnRNP F (显示 HNRNPF 蛋白)/H, which forms a novel pathway to control alternative splicing in myelinating glia.

蛋白简介QKI

蛋白简介

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Protein Quaking 蛋白 (QKI)

  • QKI, KH domain containing, RNA binding (QKI)
  • quaking (Qk)
  • 1110003F05Rik 蛋白
  • 1500005P18 蛋白
  • BqkI 蛋白
  • CQKI 蛋白
  • Hqk 蛋白
  • hqkI 蛋白
  • l(17)-1Wis 蛋白
  • l17Wis1 蛋白
  • PqkI 蛋白
  • QK 蛋白
  • QK1 蛋白
  • QK3 蛋白
  • Qki 蛋白
  • QKI-5 蛋白

Protein level used designations for Protein Quaking 蛋白 (QKI)

RNA binding protein HQK , homolog of mouse quaking QKI (KH domain RNA binding protein) , protein quaking , quaking homolog, KH domain RNA binding , RNA binding protein HQK-7B , quaking protein , RNA binding/signal transduction protein QkI-2 , QKI, KH domain containing, RNA binding tv1 , fqkI , QKI-5 protein , lethal, Chr 17, U Wisconsin 1 , rqkI

GENE ID SPECIES
9444 Homo sapiens
606754 Canis lupus familiaris
493722 Bos taurus
374204 Gallus gallus
492277 Sus scrofa
493723 Felis catus
19317 Mus musculus
499022 Rattus norvegicus
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