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PCSK9 蛋白

(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].
PCSK9 Protein (AA 31-692) (His tag) PCSK9 Protein (AA 31-692) (His tag) PCSK9 Protein (AA 31-692) (His tag) (ABIN7275415)

PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PCSK9 Protein (AA 35-694) (His tag) PCSK9 Protein (AA 35-694) (His tag) PCSK9 Protein (AA 35-694) (His tag) (ABIN7275416)

PCSK9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PCSK9 Protein (AA 31-692) (His tag) PCSK9 Protein (AA 31-692) (His tag) PCSK9 Protein (AA 31-692) (His tag) (ABIN2181580)

PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE. Active

PCSK9 蛋白 by Grade

Find PCSK9 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PCSK9 蛋白 by Origin

Find PCSK9 蛋白 for a variety of species such as anti-Human PCSK9, anti-Mouse PCSK9, anti-Rat PCSK9. The species listed below are among those available. Click on a link to go to the corresponding products.

PCSK9 蛋白 by Source

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PCSK9 蛋白 by 蛋白类型

Here you can find PCSK9 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

PCSK9 蛋白 by 应用范围

Find PCSK9 蛋白 validated for a specific application such as WB, ELISA, SDS, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PCSK9 蛋白 by 生物活性

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Popular PCSK9 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7275415
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275416
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (10)
  • (3)
Cat. No. ABIN2181580
Quantity 50 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275414
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
  • (3)
Cat. No. ABIN2444171
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6388267
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7197529
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN3013383
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320347
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094448
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136047
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2181592
Quantity 50 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2870599
Quantity 50 μg
Datasheet Datasheet
Reactivity Hamster
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2870601
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2181589
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PCSK9 蛋白

Wang, Amiss, Weidmann, Craik: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." in: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).

Burnap, Sattler, Pechlaner, Duregotti, Lu, Theofilatos, Takov, Heusch, Tsimikas, Fernandez-Hernando, Berry, Hall, Notdurfter, Rungger, Paulweber, Willeit, Kiechl, Levkau, Mayr: "PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).

Chen, Lichtor, Berliner, Chen, Liu: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).

Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

Wijers, Zanoni, Liv, Vos, Jäckstein, Smit, Wilbrink, Wolters, van der Veen, Huijkman, Dekker, Kloosterhuis, van Dijk, Billadeau, Kuipers, Klumperman, von Eckardstein, Kuivenhoven, van de Sluis: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).

Wang, Ghani, Bundock, Weidmann, Harvey, Edwards, Schroeder, Swedberg, Craik: "Calcium-Mediated Allostery of the EGF Fold." in: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).

Grin, Dwivedi, Chathely, Trigatti, Prat, Seidah, Liaw, Fox-Robichaud: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).

Dugardin, Briand, Touche, Schonewille, Moreau, Le May, Groen, Staels, Lestavel: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).

Susan-Resiga, Girard, Kiss, Essalmani, Hamelin, Asselin, Awan, Butkinaree, Fleury, Soldera, Dory, Baass, Seidah: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).

Topchiy, Cirstea, Kong, Boyd, Wang, Russell, Walley: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).

Aliases for PCSK9 蛋白

proprotein convertase subtilisin/kexin type 9 (PCSK9) 蛋白
proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) 蛋白
proprotein convertase subtilisin/kexin type 9 (pcsk9) 蛋白
proprotein convertase subtilisin/kexin type 9 (Pcsk9) 蛋白
AI415265 蛋白
AI747682 蛋白
FH3 蛋白
HCHOLA3 蛋白
LDLCQ1 蛋白
NARC-1 蛋白
NARC1 蛋白
Narc1 蛋白
PC9 蛋白
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