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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. 再加上，我们可以发KCND2 抗体 (140) 和 KCND2 蛋白 (10)和数多这个蛋白质的别的产品。
Ca(2 (显示 CA2 ELISA试剂盒)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (显示 NFATC1 ELISA试剂盒)) c4 axis is required for neuritin (显示 NRN1 ELISA试剂盒)-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Data show that suprachiasmatic nucleus (SCN (显示 SRI ELISA试剂盒)) explants from potassium channel (显示 KCNAB2 ELISA试剂盒) Kv1.4 (显示 KCNA4 ELISA试剂盒)(-/-)period2 protein Per2 (显示 PER2 ELISA试剂盒)(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2 (显示 PER2 ELISA试剂盒)(Luc) mice have significantly shorter circadian periods in PER2 (显示 PER2 ELISA试剂盒) rhythms.
Data show that potassium channel (显示 KCNAB2 ELISA试剂盒) Kv4.3 (显示 KCND3 ELISA试剂盒) outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).
This study demonstrated that Dendritic hyperexcitability induced by Kv4.2 deficiency exacerbated behavioral deficits and increased epileptiform activity amyloid protein (显示 IAPP ELISA试剂盒) precursor mutation mice.
Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 (显示 KCNIP2 ELISA试剂盒) expression was downregulated only in the H/M-Sod2 (显示 SOD2 ELISA试剂盒)(+/-)+BSO group (P<0.05).
WT PrP(C (显示 PRNP ELISA试剂盒)), in a DPP6 (显示 DPP6 ELISA试剂盒)-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude
MiR (显示 MLXIP ELISA试剂盒)-301a may be a central regulator for the expression of Kv4.2 in diabetes.
The experiments here demonstrate that Kv4.2, Kv4.3 (显示 KCND3 ELISA试剂盒) and Kv1.4 (显示 KCNA4 ELISA试剂盒) all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.
Kv4.2 regulation of excitability determines synaptic maturation site in CA1 (显示 CA1 ELISA试剂盒) hippocampal pyramidal neurons.
Kv1.4 (显示 KCNA4 ELISA试剂盒)- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN (显示 SRI ELISA试剂盒) neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN (显示 SRI ELISA试剂盒) neuron firing and locomotor behavior.
closed-state inactivation in Kv4.2 channels is a multistep process
The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry
The findings of this study suggest that variations in KCND2 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.
A rare genetic mutation of the KCND2 gene, p.D612N, was identified in a single patient. Co-expression of mutant and wild-type KCND2 with KChIP2 (显示 KCNIP2 ELISA试剂盒) demonstrated a gain-of-function phenotype.
S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 (显示 KCNC1 ELISA试剂盒) channel inactivation.
study identified a de novo variant p.Val404Met in KCND2 in a family with identical twins affected with autism and severe seizures; findings suggest KCND2 is the causal gene for epilepsy in this family and has a role in the etiology of autism
Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 (显示 KCNIP4 ELISA试剂盒) in each Kv4.2.KChIP4 (显示 KCNIP4 ELISA试剂盒) complex was dependent on the expression level of KChIP4 (显示 KCNIP4 ELISA试剂盒).
reflected in the immunoblotting data KV4.2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.
KCND2 is expressed in human skin, but has not been associated with aging.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.
potassium voltage-gated channel, Shal-related subfamily, member 2
, potassium voltage-gated channel Sha1-related subfamily member 2
, potassium voltage-gated channel subfamily D member 2
, potassium channel Kv4.2
, voltage-gated potassium channel subunit Kv4.2
, voltage-gated potassium channel Kv4.2
, voltage-sensitive potassium channel
, Potassium voltage-gated channel subfamily D member 2
, Voltage-gated potassium channel subunit Kv4.2
, potassium channel alpha subunit Kv4.2
, potassium voltage gated channel, Shal-related family, member 2