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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. 再加上，我们可以发KCNMB4 蛋白 (5)和数多这个蛋白质的别的产品。
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Mammalian Monoclonal KCNMB4 Primary Antibody for ISt, IHC - ABIN1304561
Shruti, Urban-Ciecko, Fitzpatrick, Brenner, Bruchez, Barth: The brain-specific Beta4 subunit downregulates BK channel cell surface expression. in PLoS ONE 2012
Show all 3 Pubmed References
Two recurrent fusion genes associated with the 12q locus, LRP1 (显示 LRP1 抗体)-SNRNP25 (显示 SNRNP25 抗体) and KCNMB4-CCND3 (显示 CCND3 抗体), were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
Recombinant martentoxin selectively blocks KCNMA1 (显示 KCNMA1 抗体)/KCNMB4 channels.
BK channel (显示 KCNMA1 抗体) beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases
Study shows that beta4 subunit of the MaxiK (显示 KCNMA1 抗体) channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability
IFN-gamma (显示 IFNG 抗体) changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (显示 KCNMB2 抗体) (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (显示 LRRC26 抗体) (decreased).
our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity
Report beta subunit (显示 POLG 抗体) (KNMB1-4)-specific modulations of BK channel (显示 KCNMA1 抗体) function by a Slo1 (显示 KCNMA1 抗体) mutation associated with epilepsy and dyskinesia.
results argue that, for native mouse Slo3 (显示 KCNU1 抗体) channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 (显示 KCNMA1 抗体) alpha subunit (显示 POLG 抗体)
conclude that seizure-induced downregulation of KCNMB4 is an activity dependent mechanism that increases the excitability of DG neurons. These novel findings indicate that BK channel (显示 KCNMA1 抗体) subtypes are not only defined by cell-specific expression, but can also be plastic depending on the recent history of neuronal excitability
These results indicate that an important role of the beta4-subunit is to reduce ryanodine receptor (显示 RYR3 抗体)-BK channel (显示 KCNMA1 抗体) functional coupling during the afterhyperpolarization component of the action potential, thereby decreasing excitability of dentate gyrus neurons.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC (显示 SCNN1A 抗体)-mediated sodium reabsorption
BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining potassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.
E2 at physiological concentrations augments K(Ca) currents through ERbeta (显示 ESR2 抗体) in the GT1 (显示 MYL4 抗体)-7 GnRH (显示 GNRH1 抗体) neuronal cell line and increases the expression of the BK channel (显示 KCNMA1 抗体) subunit mRNAs, alpha and beta4
The study verified that the BK(Ca) channel alpha-subunit (显示 POLG 抗体) is located to smooth muscle cells of porcine basilar and middle cerebral arteries.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
BK channel subunit beta-4
, calcium activated potassium channel beta 4 subunit
, calcium-activated potassium channel subunit beta-4
, calcium-activated potassium channel, subfamily M subunit beta-4
, charybdotoxin receptor subunit beta-4
, maxi K channel subunit beta-4
, large conductance calcium-dependent potassium ion channel beta 4 subunit
, Slowpoke beta 4
, calcium-activated potassium channel beta 4 subunit
, potassium large conductance calcium-activated channel, subfamily M, beta member 4
, large calcium-activated potassium channel subfamily M beta member 4