anti-Poly A Specific Ribonuclease (PARN) 抗体

The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. 再加上,我们可以发PARN 蛋白 (15)PARN 试剂盒 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PARN 5073 O95453
PARN 360464  
PARN 74108 Q8VDG3

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Showing 10 out of 66 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-PARN Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>SP2/0 cell lysate 100 μL Log in to see 5至7个工作日
¥16,831.21
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Bat 非结合性 WB 100 μg Log in to see 29至35个工作日
¥4,989.82
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非结合性 ELISA, IF, IHC, WB 100 μL Log in to see 34至38个工作日
¥4,371.67
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小鼠 非结合性 ELISA, WB 100 μg Log in to see 24至29个工作日
¥3,531.31
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非结合性 IP, WB Western Blot: PARN Antibody [NBP2-19696] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: BCL-1 7. 5% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
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小鼠 非结合性 IHC, WB Immunohistochemistry: PARN Antibody (4D12) [NBP2-46321] - Analysis of Adenocarcinoma of Human breast tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: PARN Antibody (4D12) [NBP2-46321] - Analysis of Carcinoma of Human liver tissue.(Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 26至33个工作日
¥3,655.56
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非结合性 WB Western Blot: PARN Antibody [NBP1-80250] - Lanes: Lane 1 : 7ug HEK293 cytoplasmic lysate 2: 7ug HEK293 nuclei lysate Primary, Antibody Dilution: 1 : 500 Secondary Antibody: Anti-rabbit-HRP Secondary, Antibody Dilution: 1 : 500 Gene name: PARN. Western Blot: PARN Antibody [NBP1-80250] - SP2/0 cell lysate, concentration 1.25ug/ml. 100 μL Log in to see 26至33个工作日
¥3,333.96
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非结合性 IC, IF, IHC, WB Immunofluorescent analysis of PARN staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of PARN staining in human esophageal cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated 200 μL Log in to see 7至8个工作日
¥3,981.76
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小鼠 非结合性 WB   100 μL Log in to see 29至35个工作日
¥4,989.82
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小鼠 非结合性 IHC (p), WB   100 μL Log in to see 29至35个工作日
¥4,989.82
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通过反应活性、应用领域、克隆类型和共轭标记 PARN 抗体

特性 应用范围 宿主 克隆类型 标记
Human
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,
, ,
Rat (Rattus)


Mouse (Murine)


更多抗PARN的相互作用对抗体

Human Poly A Specific Ribonuclease (PARN) interaction partners

  1. PARN is a new component of the ribosome biogenesis machinery in human cells.

  2. provide evidence that PARN can also deadenylate the U6 and RMRP (显示 NME1 抗体) RNAs without affecting their levels

  3. poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells

  4. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (显示 PABPN1 抗体) and the poly(A)-specific RNase PARN.

  5. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (显示 EXOSC10 抗体).

  6. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.

  7. results highlight the clinical significance of PARN and NOC on the survival in SCC (显示 CYP11A1 抗体) diagnosed patients.

  8. Mutations in the PARN gene cause dyskeratosis congenital.

  9. The results indicate that the cellular level of miR (显示 MLXIP 抗体)-122 is determined by the balance between the opposing effects of GLD-2 (显示 PAPD4 抗体) and PARN/CUGBP1 (显示 CELF1 抗体) on the metabolism of its 3'-terminus.

  10. 3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1 (显示 DKC1 抗体), RTEL1 (显示 RTEL1 抗体), and TERF1 (显示 TERF1 抗体).

Mouse (Murine) Poly A Specific Ribonuclease (PARN) interaction partners

  1. these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.

  2. poly(A) polymerase (显示 PAPOLA 抗体) Gld2 (显示 PAPD4 抗体), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (显示 NGDN 抗体)) are components of a dendritic CPEB (显示 CPEB1 抗体)-associated polyadenylation apparatus

  3. Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.

  4. A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.

PARN 抗原简介

蛋白简介

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PARN

  • poly(A)-specific ribonuclease (parn) 抗体
  • poly(A)-specific ribonuclease (PARN) 抗体
  • poly(A)-specific ribonuclease (Parn) 抗体
  • poly(A)-specific ribonuclease (deadenylation nuclease) (parn) 抗体
  • poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 抗体
  • 1200003I18Rik 抗体
  • DAN 抗体
  • parn-A 抗体
  • RGD1565449 抗体
  • xparn 抗体
  • zgc:56067 抗体

Protein level used designations for PARN

deadenylating nuclease , deadenylation nuclease , poly(A)-specific ribonuclease (deadenylation nuclease) , poly(A)-specific ribonuclease PARN , polyadenylate-specific ribonuclease

GENE ID SPECIES
394409 Xenopus laevis
5073 Homo sapiens
479839 Canis lupus familiaris
524155 Bos taurus
360464 Rattus norvegicus
100172259 Pongo abelii
791461 Danio rerio
74108 Mus musculus
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