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The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. 再加上，我们可以发PARN 蛋白 (15) 和 PARN 试剂盒 (12)和数多这个蛋白质的别的产品。
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PARN is a new component of the ribosome biogenesis machinery in human cells.
provide evidence that PARN can also deadenylate the U6 and RMRP (显示 NME1 抗体) RNAs without affecting their levels
poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells
we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (显示 PABPN1 抗体) and the poly(A)-specific RNase PARN.
PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (显示 EXOSC10 抗体).
Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.
results highlight the clinical significance of PARN and NOC on the survival in SCC (显示 CYP11A1 抗体) diagnosed patients.
Mutations in the PARN gene cause dyskeratosis congenital.
The results indicate that the cellular level of miR (显示 MLXIP 抗体)-122 is determined by the balance between the opposing effects of GLD-2 (显示 PAPD4 抗体) and PARN/CUGBP1 (显示 CELF1 抗体) on the metabolism of its 3'-terminus.
3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1 (显示 DKC1 抗体), RTEL1 (显示 RTEL1 抗体), and TERF1 (显示 TERF1 抗体).
these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.
poly(A) polymerase (显示 PAPOLA 抗体) Gld2 (显示 PAPD4 抗体), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (显示 NGDN 抗体)) are components of a dendritic CPEB (显示 CPEB1 抗体)-associated polyadenylation apparatus
Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.
A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, deadenylation nuclease
, poly(A)-specific ribonuclease (deadenylation nuclease)
, poly(A)-specific ribonuclease PARN
, polyadenylate-specific ribonuclease