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PLEC 抗体

(Plectin (PLEC))
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011].
PLEC 抗体  (AA 1744-1929) PLEC 抗体  (AA 1744-1929) PLEC 抗体 (AA 1744-1929) (ABIN7163687)

PLEC 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

PLEC 抗体  (AA 4384-4493) PLEC 抗体  (AA 4384-4493) PLEC 抗体 (AA 4384-4493) (ABIN518954)

PLEC 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 4C3 unconjugated

PLEC 抗体  (Middle Region) PLEC 抗体  (Middle Region) PLEC 抗体 (Middle Region) (ABIN3043900)

PLEC 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

PLEC 抗体 by Grade

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PLEC 抗体 by 适用

Find PLEC 抗体 for a variety of species such as anti-Human PLEC, anti-Mouse PLEC, anti-Rat PLEC. The species listed below are among those available. Click on a link to go to the corresponding products.

PLEC 抗体 by 应用范围

Find PLEC 抗体 validated for a specific application such as ELISA, IF (cc), IF (p), WB. Some of the available applications are listed below. Click on a link to go to the corresponding products.

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PLEC 抗体 by 抗原表位

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PLEC 抗体 by 克隆形成能力

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PLEC 抗体 by 克隆

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PLEC 抗体 by 标记

Find PLEC 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular PLEC 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7163687
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (3)
Cat. No. ABIN518954
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN3043900
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, WB, IP, ICC
Validations
  • (2)
Cat. No. ABIN7435127
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6242818
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN518953
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN6264300
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7243751
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC (p)
Validations
  • (1)
Cat. No. ABIN7489970
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
Cat. No. ABIN701965
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN701967
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN911383
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN911387
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN911384
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN2805423
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our PLEC 抗体

Domke, Franke et al.: "The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic ..." in: Cell and tissue research, Vol. 375, Issue 2, pp. 451-482, (2019) (PubMed).

Liu, Wu, Lin, Liu, Chen: "[Fusion expression of SLT-IIeB gene and FedF gene of Ee in Escherichia coli and its immunogenicity]" in: Wei sheng wu xue bao = Acta microbiologica Sinica, Vol. 47, Issue 6, pp. 1044-9, (2008) (PubMed).

Banwell, Russel, Fukudome, Shen, Stilling, Engel: "Myopathy, myasthenic syndrome, and epidermolysis bullosa simplex due to plectin deficiency." in: Journal of neuropathology and experimental neurology, Vol. 58, Issue 8, pp. 832-46, (1999) (PubMed).

Andrä, Nikolic, Stöcher, Drenckhahn, Wiche: "Not just scaffolding: plectin regulates actin dynamics in cultured cells." in: Genes & development, Vol. 12, Issue 21, pp. 3442-51, (1998) (PubMed).

Liu, Maercker, Castañon, Hauptmann, Wiche: "Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 9, pp. 4278-83, (1996) (PubMed).

Wiche, Krepler, Artlieb, Pytela, Denk: "Occurrence and immunolocalization of plectin in tissues." in: The Journal of cell biology, Vol. 97, Issue 3, pp. 887-901, (1983) (PubMed).

Aliases for PLEC 抗体

plectin (LOC100481602) 抗体
plectin L homeolog (plec.L) 抗体
plectin (PLEC) 抗体
plectin (Plec) 抗体
plectin (LOC786966) 抗体
AA591047 抗体
AU042537 抗体
EBS1 抗体
EBSO 抗体
HD1 抗体
IFAP300 抗体
LGMD2Q 抗体
PCN 抗体
Pcn 抗体
PLEC1 抗体
Plec1 抗体
PLEC1b 抗体
Plectin-1 抗体
PLTN 抗体
Pltn 抗体
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