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PGC encodes an aspartic proteinase that belongs to the peptidase family A1. 再加上，我们可以发PGC 抗体 (165) 和 PGC 试剂盒 (56)和数多这个蛋白质的别的产品。
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Pepsinogen-II 100 bp ins (显示 INS 蛋白)/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.
Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.
Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (显示 PTPN11 蛋白), and IL1B (显示 IL1B 蛋白), are associated with susceptibility to gastric carcinogenesis.
Serum pepsinogens I (PGI (显示 BGN 蛋白)) and II (PGII (显示 DCN 蛋白)), gastrin (显示 GAST 蛋白) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (显示 S100A8 蛋白)) antigen among 309 consecutive patients, were measured.
The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (显示 ERCC6 蛋白) rs1917799 polymorphism was observed for the risk of gastric cancer.
Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (显示 FAS 蛋白) and may be involved in the pathogenesis of OME.
High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis.
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
, pepsinogen C
, pepsin C
, pepsinogen group II
, urinary pepsinogen 1
, Urinary pepsinogen 1