Pepsinogen C 蛋白 (PGC)

PGC encodes an aspartic proteinase that belongs to the peptidase family A1. 再加上,我们可以发PGC 抗体 (164)PGC 试剂盒 (52)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
PGC 5225 P20142
PGC 109820 Q9D7R7
PGC 24864 P04073

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Showing 10 out of 22 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
人细胞 His tag 10 μg Log in to see 14至15个工作日
¥2,465.63
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人细胞 大鼠 His tag 10 μg Log in to see 14至15个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 9至12个工作日
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大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 9至12个工作日
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
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HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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HOST_Human 非结合性   100 μg Log in to see 28至34个工作日
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大肠杆菌(E. Coli) His tag 50 μg Log in to see 14至15个工作日
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PGC 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus) , ,

引用最多的PGC 蛋白

  1. Human PGC Protein expressed in Human Cells - ABIN2005019 : Moore, Sielecki, Chernaia, Tarasova, James: Crystal and molecular structures of human progastricsin at 1.62 A resolution. in Journal of molecular biology 1995 (PubMed)
    Show all 2 references for 2005019

  2. Rat (Rattus) PGC Protein expressed in Human Cells - ABIN2009149 : Khan, Cherney, Tarasova, James: Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. in Nature structural biology 1998 (PubMed)
    Show all 2 references for 2009149

更多Pepsinogen C (PGC)互动伙伴

Human Pepsinogen C (PGC) interaction partners

  1. Pepsinogen-II 100 bp ins (显示 INS 蛋白)/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.

  2. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.

  3. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (显示 PTPN11 蛋白), and IL1B (显示 IL1B 蛋白), are associated with susceptibility to gastric carcinogenesis.

  4. Serum pepsinogens I (PGI (显示 BGN 蛋白)) and II (PGII (显示 DCN 蛋白)), gastrin (显示 GAST 蛋白) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (显示 S100A8 蛋白)) antigen among 309 consecutive patients, were measured.

  5. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.

  6. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.

  7. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.

  8. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (显示 ERCC6 蛋白) rs1917799 polymorphism was observed for the risk of gastric cancer.

  9. Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (显示 FAS 蛋白) and may be involved in the pathogenesis of OME.

  10. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis.

蛋白简介PGC

蛋白简介

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene names and symbols associated with Pepsinogen C 蛋白 (PGC)

  • progastricsin (pepsinogen C) (PGC)
  • progastricsin (pepsinogen C) (Pgc)
  • 2210410L06Rik 蛋白
  • CPGC 蛋白
  • Gastricsin 蛋白
  • PEPC 蛋白
  • Pg-1 蛋白
  • PG1 蛋白
  • PGC 蛋白
  • PGII 蛋白
  • PGNC 蛋白
  • Upg-1 蛋白
  • Upg1 蛋白

Protein level used designations for Pepsinogen C 蛋白 (PGC)

gastricsin , pepsinogen C , pepsin C , pepsinogen group II , preprogastricsin , urinary pepsinogen 1 , Urinary pepsinogen 1 , gastricsin-like

GENE ID SPECIES
554184 Monodelphis domestica
5225 Homo sapiens
109820 Mus musculus
395690 Gallus gallus
24864 Rattus norvegicus
100009323 Oryctolagus cuniculus
100135598 Cavia porcellus
100404738 Callithrix jacchus
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