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PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. 再加上，我们可以发PHF2 抗体 (38) 和 PHF2 蛋白 (3)和数多这个蛋白质的别的产品。
these results demonstrate that PHF2 histone demethylase (显示 MBD2 ELISA试剂盒) controls adipogenic gene expression during differentiation.
PHF2 enhances osteoblast differentiation by demethylating Runx2 (显示 RUNX2 ELISA试剂盒), while suppressor of variegation 3-9 homolog 1 (SUV39H1 (显示 SUV39H1 ELISA试剂盒)) inhibits bone formation by methylating it.
Arid5b (显示 ARID5B ELISA试剂盒) recruits Phf2 to the promoter region of Sox9 (显示 SOX9 ELISA试剂盒) target genes and stimulates H3K9me2 demethylation of these genes.
Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha (显示 CEBPA ELISA试剂盒)) gene and demethylates histones in chromatin.
histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation
PHF2 (显示 PHF1 ELISA试剂盒) acts as a tumor suppressor in association with p53 (显示 TP53 ELISA试剂盒) in cancer development and ensures p53 (显示 TP53 ELISA试剂盒)-mediated cell death in response to chemotherapy.
PHF2 (显示 PHF1 ELISA试剂盒) is likely to repress rDNA transcription by competing with PHF8 (显示 PHF8 ELISA试剂盒) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (显示 SUV39H1 ELISA试剂盒).
JARID1B and PHF2 (显示 PHF1 ELISA试剂盒) are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression
the crystal structures of PHF2 (显示 PHF1 ELISA试剂盒) Jumonji (显示 JARID2 ELISA试剂盒) domain in the absence and presence of additional exogenous metal ions were determined.
Differential association of alterations in FANCC (显示 FANCC ELISA试剂盒) and PTCH1 (显示 PTCH1 ELISA试剂盒) with that of PHF2 (显示 PHF1 ELISA试剂盒), XPA (显示 XPA ELISA试剂盒) and two breast cancer susceptibility genes (BRCA1/BRCA2 (显示 BRCA2 ELISA试剂盒)) in the two age groups suggests differences in their molecular pathogenesis.
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
PHD finger protein 2
, polycomb-like protein 1
, t-complex testis-expressed 3
, centromere protein 35
, jumonji C domain-containing histone demethylase 1E
, lysine-specific demethylase PHF2
, PHD finger protein 8
, lysine-specific demethylase phf2