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OSBPL6 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. 再加上，我们可以发Oxysterol Binding Protein-Like 6 蛋白 (6)和数多这个蛋白质的别的产品。
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family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (显示 PTPRG 抗体), OSBPL6, and PDCL3 (显示 PDCL3 抗体) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (显示 PTPRG 抗体), rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3 (显示 PDCL3 抗体). In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 (显示 CDKAL1 抗体) showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR (显示 MLXIP 抗体)-33 and miR (显示 MLXIP 抗体)-27b target gene networks contributing to the maintenance of cholesterol homeostasis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
, OSBP-related protein 6
, oxysterol-binding protein-related protein 6