Ornithine Decarboxylase Antizyme 1 蛋白 (OAZ1)

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. 再加上,我们可以发OAZ1 抗体 (30)OAZ1 试剂盒 (9)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
OAZ1 4946 P54368
OAZ1 18245 P54369
OAZ1 25502 P54370

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OAZ1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,

Mouse (Murine)

Rat (Rattus)

引用最多的OAZ1 蛋白

  1. Human OAZ1 Protein expressed in Escherichia coli (E. coli) - ABIN1098382 : Aoto, Miyake, Nakamura, Tajima: Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids. in Genomics 1997 (PubMed)
    Show all 2 references for 1098382

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Human Ornithine Decarboxylase Antizyme 1 (OAZ1) interaction partners

  1. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).

  2. Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells.

  3. To further understand its functions in CML (显示 BCR 蛋白) pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development.

  4. Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders.

  5. In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 (显示 CRTC2 蛋白) is activated, leading to the inhibition of global protein synthesis and increased AZ1 synthesis via a cap-independent mechanism.

  6. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC (显示 ODC1 蛋白) and AZI and inhibition of their function.

  7. the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities

  8. Data show that OAZ promotes the removal of Mps1 (显示 IDUA 蛋白) from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1 (显示 IDUA 蛋白).

  9. These data together demonstrate the existence of a c-Jun (显示 JUN 蛋白)-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.

  10. Human AZI is capable of acting as a general inhibitor for all members of the antizyme family.

Mouse (Murine) Ornithine Decarboxylase Antizyme 1 (OAZ1) interaction partners

  1. Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).

  2. we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences

  3. Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53 (显示 TP53 蛋白).

  4. The activity of AZ1 was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation.

  5. These data together demonstrate the existence of a c-Jun (显示 JUN 蛋白)-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.

  6. Testosterone treatment enhanced AZ1 and N1-SSAT (显示 SAT1 蛋白) mRNA levels in a time-dependent manner

  7. antizyme and glycosaminoglycans have roles in polyamine transport

  8. OAZ can alter the intensity and duration of the BMP4 (显示 BMP4 蛋白) stimulus through Smad6 (显示 SMAD6 蛋白)

  9. Az-1 has a central and meaningful role in modulation of polyamine homeostasis, and in regulating cellular proliferation and transformation properties.

  10. The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and Ornithine Decarboxylase (ODC (显示 ODC1 蛋白)).

Xenopus laevis Ornithine Decarboxylase Antizyme 1 (OAZ1) interaction partners

  1. antizyme expression requires programmed,+1 ribosomal frameshifting

蛋白简介OAZ1

蛋白简介

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.

Gene names and symbols associated with OAZ1

  • ornithine decarboxylase antizyme 1 (OAZ1)
  • ornithine decarboxylase antizyme 1 (Oaz1)
  • ornithine decarboxylase antizyme 1 (oaz1)
  • ornithine decarboxylase antizyme 1a (oaz1a)
  • Antizyme 蛋白
  • AZ-1 蛋白
  • AZ1 蛋白
  • AZI 蛋白
  • AZS 蛋白
  • oaz 蛋白
  • oaz1 蛋白
  • ODC-Az 蛋白
  • ODCAC 蛋白

Protein level used designations for OAZ1

ODC-Az , antizyme 1 , ODC antizyme , ODC-Az-S , ornithine decarboxylase antizyme 1

GENE ID SPECIES
4946 Homo sapiens
18245 Mus musculus
25502 Rattus norvegicus
506973 Bos taurus
395746 Gallus gallus
379737 Xenopus laevis
101826304 Mesocricetus auratus
259192 Danio rerio
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