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Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. 再加上，我们可以发Organic Solute Transporter alpha 抗体 (23) 和 Organic Solute Transporter alpha 试剂盒 (3)和数多这个蛋白质的别的产品。
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SLC51A expression is significantly upregulated in human masticatory mucosa during wound healing
Hepatic OSTalpha-OSTbeta (显示 OSTBETA 蛋白) expression is induced by hypoxia.
Ostbeta (显示 OSTBETA 蛋白) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (显示 OSTBETA 蛋白) critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (显示 OSTBETA 蛋白) in different tissues.
OSTalpha has roles in biological transport and is widely expressed in human tissues
overexpression of hu (显示 OSTBETA 蛋白)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (显示 NR1H4 蛋白) and the activation of FXR target genes
OSTalpha/OSTbeta (显示 OSTBETA 蛋白) expression is induced by bile acids through ligand-dependent transactivation of both OST (显示 DDOST 蛋白) genes by the nuclear bile acid receptor (显示 NR1H4 蛋白)/farnesoid X receptor (显示 xpr1 蛋白) (FXR (显示 NR1H4 蛋白)).
the selective localization of OSTalpha and OSTbeta (显示 OSTBETA 蛋白) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
These results indicate that expression of Ostalpha and Ostbeta (显示 OSTBETA 蛋白) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (显示 NR1H4 蛋白).
Demonstrate association of OST-alpha and OST-beta (显示 OSTBETA 蛋白) to determine trafficking to plasma membrane and activity.
Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit (显示 OSTBETA 蛋白)) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB (显示 OSTBETA 蛋白) are inactive.
These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (显示 INS 蛋白) resistance.
Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (显示 APOE 蛋白)(-/-) mice deficient in Ostalpha.
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Inactivation of FXR (显示 NR1H4 蛋白) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.
Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.
OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (显示 SULT2A1 蛋白) homeostasis
These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.
Co-expression of mouse Ostalpha-Ostbeta (显示 OSTBETA 蛋白), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha and OSTbeta (显示 OSTBETA 蛋白) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (显示 NR1H4 蛋白)-/-, mice
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter alpha
, organic solute transporter subunit alpha
, organic solute transporter, alpha subunit
, solute carrier family 51 subunit alpha