Organic Solute Transporter alpha 蛋白 (OSTALPHA)

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. 再加上,我们可以发Organic Solute Transporter alpha 抗体 (23)Organic Solute Transporter alpha 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 OSTALPHA OSTALPHA 303879  
OSTALPHA 200931 Q86UW1
OSTALPHA 106407 Q8R000

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 68至77个工作日
¥106,677.42
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 68至77个工作日
¥151,831.10
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小麦胚 GST tag 2 μg Log in to see 29至34个工作日
¥2,017.10
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OSTALPHA 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

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Human Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. SLC51A expression is significantly upregulated in human masticatory mucosa during wound healing

  2. Hepatic OSTalpha-OSTbeta (显示 OSTBETA 蛋白) expression is induced by hypoxia.

  3. Ostbeta (显示 OSTBETA 蛋白) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (显示 OSTBETA 蛋白) critical for these processes.

  4. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (显示 OSTBETA 蛋白) in different tissues.

  5. OSTalpha has roles in biological transport and is widely expressed in human tissues

  6. overexpression of hu (显示 OSTBETA 蛋白)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (显示 NR1H4 蛋白) and the activation of FXR target genes

  7. OSTalpha/OSTbeta (显示 OSTBETA 蛋白) expression is induced by bile acids through ligand-dependent transactivation of both OST (显示 DDOST 蛋白) genes by the nuclear bile acid receptor (显示 NR1H4 蛋白)/farnesoid X receptor (显示 xpr1 蛋白) (FXR (显示 NR1H4 蛋白)).

  8. the selective localization of OSTalpha and OSTbeta (显示 OSTBETA 蛋白) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  9. These results indicate that expression of Ostalpha and Ostbeta (显示 OSTBETA 蛋白) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (显示 NR1H4 蛋白).

  10. Demonstrate association of OST-alpha and OST-beta (显示 OSTBETA 蛋白) to determine trafficking to plasma membrane and activity.

Mouse (Murine) Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit (显示 OSTBETA 蛋白)) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB (显示 OSTBETA 蛋白) are inactive.

  2. These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (显示 INS 蛋白) resistance.

  3. Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (显示 APOE 蛋白)(-/-) mice deficient in Ostalpha.

  4. Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression

  5. Inactivation of FXR (显示 NR1H4 蛋白) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.

  6. Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.

  7. OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (显示 SULT2A1 蛋白) homeostasis

  8. These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.

  9. Co-expression of mouse Ostalpha-Ostbeta (显示 OSTBETA 蛋白), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate

  10. OSTalpha and OSTbeta (显示 OSTBETA 蛋白) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (显示 NR1H4 蛋白)-/-, mice

蛋白简介Organic Solute Transporter alpha (OSTALPHA)

蛋白简介

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).

Gene names and symbols associated with OSTALPHA

  • solute carrier family 51, alpha subunit (Slc51a)
  • solute carrier family 51, alpha subunit (SLC51A)
  • AV001382 蛋白
  • AW261577 蛋白
  • D630035O19Rik 蛋白
  • OSTA 蛋白
  • OSTALPHA 蛋白
  • RGD1311100 蛋白

Protein level used designations for OSTALPHA

organic solute transporter alpha , organic solute transporter subunit alpha , OST-alpha , organic solute transporter, alpha subunit , solute carrier family 51 subunit alpha

GENE ID SPECIES
303879 Rattus norvegicus
200931 Homo sapiens
106407 Mus musculus
516626 Bos taurus
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