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Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. 再加上，我们可以发Organic Solute Transporter alpha 抗体 (23) 和 Organic Solute Transporter alpha 蛋白 (3)和数多这个蛋白质的别的产品。
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SLC51A expression is significantly upregulated in human masticatory mucosa during wound healing
Hepatic OSTalpha-OSTbeta (显示 OSTBETA ELISA试剂盒) expression is induced by hypoxia.
Ostbeta (显示 OSTBETA ELISA试剂盒) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (显示 OSTBETA ELISA试剂盒) critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (显示 OSTBETA ELISA试剂盒) in different tissues.
OSTalpha has roles in biological transport and is widely expressed in human tissues
overexpression of hu (显示 OSTBETA ELISA试剂盒)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (显示 NR1H4 ELISA试剂盒) and the activation of FXR target genes
OSTalpha/OSTbeta (显示 OSTBETA ELISA试剂盒) expression is induced by bile acids through ligand-dependent transactivation of both OST (显示 DDOST ELISA试剂盒) genes by the nuclear bile acid receptor (显示 NR1H4 ELISA试剂盒)/farnesoid X receptor (FXR (显示 NR1H4 ELISA试剂盒)).
the selective localization of OSTalpha and OSTbeta (显示 OSTBETA ELISA试剂盒) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
These results indicate that expression of Ostalpha and Ostbeta (显示 OSTBETA ELISA试剂盒) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (显示 NR1H4 ELISA试剂盒).
Demonstrate association of OST-alpha and OST-beta (显示 OSTBETA ELISA试剂盒) to determine trafficking to plasma membrane and activity.
Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit (显示 OSTBETA ELISA试剂盒)) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB (显示 OSTBETA ELISA试剂盒) are inactive.
These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (显示 INS ELISA试剂盒) resistance.
Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (显示 APOE ELISA试剂盒)(-/-) mice deficient in Ostalpha.
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Inactivation of FXR (显示 NR1H4 ELISA试剂盒) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.
Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.
OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (显示 SULT2A1 ELISA试剂盒) homeostasis
These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.
Co-expression of mouse Ostalpha-Ostbeta (显示 OSTBETA ELISA试剂盒), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha and OSTbeta (显示 OSTBETA ELISA试剂盒) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (显示 NR1H4 ELISA试剂盒)-/-, mice
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter alpha
, organic solute transporter subunit alpha
, organic solute transporter, alpha subunit
, solute carrier family 51 subunit alpha