NUDT1 抗体
(Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008].
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NUDT1 抗体 by Grade
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NUDT1 抗体 by 适用
Find NUDT1 抗体 for a variety of species such as anti-Human NUDT1, anti-Mouse NUDT1, anti-Rat NUDT1. The species listed below are among those available. Click on a link to go to the corresponding products.
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NUDT1 抗体 by 抗原表位
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NUDT1 抗体 by 克隆形成能力
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NUDT1 抗体 by 克隆
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NUDT1 抗体 by 标记
Find NUDT1 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular NUDT1 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
IHC, ELISA, IF
Validations
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Cat. No.
ABIN7142858
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
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Cat. No.
ABIN518070
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC
Validations
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Cat. No.
ABIN7256838
Quantity
200 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
ABIN561864
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IF, IHC (p)
Validations
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Cat. No.
ABIN5584835
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN6144926
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6263763
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IF, ICC, IHC (fro)
Validations
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- (1)
Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB
Validations
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Cat. No.
ABIN1989517
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
ABIN5584834
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7142861
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7142859
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF
Validations
Cat. No.
ABIN7117074
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IP
Validations
Cat. No.
ABIN6759298
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our NUDT1 抗体
: "The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress." in: Mutation research, Vol. 808, pp. 10-19, (2019) (PubMed).: "The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia." in: BMC cancer, Vol. 18, Issue 1, pp. 1190, (2019) (PubMed).
: "Potent and specific MTH1 inhibitors targeting gastric cancer." in: Cell death & disease, Vol. 10, Issue 6, pp. 434, (2019) (PubMed).
: "Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue." in: DNA repair, pp. 102644, (2019) (PubMed).
: "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. ..." in: Nature communications, Vol. 9, Issue 1, pp. 250, (2018) (PubMed).
: "Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway." in: Journal of lipid research, Vol. 59, Issue 5, pp. 830-842, (2018) (PubMed).
: "Validating the concept of mutational signatures with isogenic cell models." in: Nature communications, Vol. 9, Issue 1, pp. 1744, (2018) (PubMed).
: "hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia." in: Oncogenesis, Vol. 5, Issue 12, pp. e275, (2016) (PubMed).
: "Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma." in: International journal of hematology, Vol. 105, Issue 3, pp. 318-325, (2016) (PubMed).
: "MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways." in: Oncogene, Vol. 34, Issue 20, pp. 2586-96, (2015) (PubMed).
Aliases for NUDT1 抗体
7,8-dihydro-8-oxoguanine triphosphatase (mth1) 抗体7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) 抗体
nudix hydrolase 1 (nudt1) 抗体
7,8-dihydro-8-oxoguanine triphosphatase (8odp) 抗体
nudix hydrolase 1 (NUDT1) 抗体
nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) 抗体
nudix hydrolase 1 (Nudt1) 抗体
MTH1 抗体
Mth1 抗体
mutT 抗体
nudT1 抗体
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