Neutrophil Cytosolic Factor 2 蛋白 (NCF2)

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. 再加上,我们可以发NCF2 抗体 (50)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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NCF2 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

更多Neutrophil Cytosolic Factor 2 (NCF2)互动伙伴

Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. analysis of NCF2, BCKDHB (显示 BCKDHB 蛋白) and BCKDHA (显示 BCKDHA 蛋白) in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (显示 NCF4 蛋白) and p67phox at the phagosomal membrane.

  2. TLR4 (显示 TLR4 蛋白)- and TLR2-induced IRAK (显示 IRAK1 蛋白)-ERK (显示 EPHB2 蛋白) pathway cross-talks with p67phox-Nox-2 (显示 CYBB 蛋白) for reactive oxygen species generation, thus regulating IL-1beta (显示 IL1B 蛋白) transcription and processing in monocytic cells.

  3. Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 蛋白) subunits p22(phox (显示 CYBA 蛋白)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA 蛋白)) and p67(phox) expression was attenuated by exercise training in obese subjects.

  4. A novel homozygous mutation in NCF2.

  5. results reveal an essential role for the Cys (显示 DNAJC5 蛋白)-Gly-Cys (显示 DNAJC5 蛋白) triad in Nox2 (显示 CYBB 蛋白) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (显示 DNAJC5 蛋白)-Gly-Cys (显示 DNAJC5 蛋白). The 2 regions interact with distinct partner sites in p67(phox).

  6. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (显示 NCF4 蛋白)/VAV1 (显示 VAV1 蛋白)/RAC1 NADPH oxidase (显示 NOX1 蛋白) complex.

  7. Data indicate that arachidonic acid induces the direct interaction of Rac (显示 AKT1 蛋白)-GTP (显示 AK3 蛋白)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (显示 NOX1 蛋白) Nox2 (显示 CYBB 蛋白).

  8. Four novel mutations in the NCF1 (显示 NCF1 蛋白), NCF2, and CYBB (显示 CYBB 蛋白) genees have been identified in chronic granulomatous disease patients in Morocco.

  9. Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.

  10. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Just as patients with chronic granulomatous disease who lack NADPH oxidase (显示 NOX1 蛋白) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  2. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (显示 PLA2G2A 蛋白) activity, an interaction that could function to terminate the PLA2 (显示 PLA2G2A 蛋白)-mediated NOX2 (显示 CYBB 蛋白) activation signal.

  3. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (显示 FDXR 蛋白) oxidasesubunit (67kDa (显示 RPSA 蛋白)) and the resultant metabolic oxidative stress.

  4. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (显示 CYBB 蛋白)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (显示 SLC2A4 蛋白)-/-) mice.

  5. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  6. This study demonstrates the involvement of ROS (显示 ROS1 蛋白) from NADPH oxidase (显示 NOX1 蛋白) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (显示 PKCd 蛋白)- and ERK (显示 EPHB2 蛋白)-dependent pathways.

蛋白简介NCF2

蛋白简介

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with NCF2

  • neutrophil cytosolic factor 2 (NCF2)
  • neutrophil cytosolic factor 2 (ncf2)
  • neutrophil cytosolic factor 2 (p67phox)
  • neutrophil cytosol factor 2 (VDBG_06643)
  • neutrophil cytosolic factor 2 (PGTG_05816)
  • neutrophil cytosolic factor 2 (LOC100136240)
  • neutrophil cytosolic factor 2 (Ncf2)
  • MGC81877 蛋白
  • Ncf-2 蛋白
  • NOXA2 蛋白
  • P67-PHOX 蛋白
  • P67PHOX 蛋白
  • zgc:158405 蛋白

Protein level used designations for NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

GENE ID SPECIES
424445 Gallus gallus
444487 Xenopus laevis
457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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