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NSMAF encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. 再加上，我们可以发Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 试剂盒 (7) 和 Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 蛋白 (5)和数多这个蛋白质的别的产品。
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The interaction of FAN with receptor for activated C-kinase 1 (RACK1 (显示 GNB2L1 抗体)) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN.
sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase (显示 SMPD1 抗体)
Regulation of NSMAF by TNF-alpha (显示 TNF 抗体) involves PRKCD (显示 PKCd 抗体) in lung epithelial cells.
FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor (显示 TNF 抗体).
FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis.
the role of FAN and IL-6 (显示 IL6 抗体) in the inflammatory response initiated by endotoxin, implicating TNFalpha (显示 TNF 抗体)
FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC.
The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in tumor necrosis factor (显示 TNF 抗体)-induced Cdc42 (显示 CDC42 抗体) activation and cytoskeleton reorganization.
This is the first report to demonstrate that TNFalpha (显示 TNF 抗体)-induced sickness behavior is fully mediated by TNF-R1 (显示 TNFRSF1A 抗体) and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior
these results indicate the involvement of FAN in TNF (显示 TNF 抗体)-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
, factor associated with N-SMase activation
, factor associated with neutral sphingomyelinase activation