anti-Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) 抗体

NSMAF encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. 再加上,我们可以发Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 试剂盒 (5)Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NSMAF 8439 Q92636
NSMAF 18201 O35242
NSMAF 353233  

antibodies-online.cn销售最多的anti-Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 抗体

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 IHC (p), WB NSMAF Antibody (N-term) (ABIN657508) western blot analysis in mouse cerebellum tissue lysates (35 µg/lane). This demonstrates the NSMAF antibody detected the NSMAF protein (arrow). 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 WB   0.1 mg Log in to see 29至35个工作日
¥4,187.20
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非结合性 WB   0.1 mg Log in to see 29至35个工作日
¥5,297.02
详细
非结合性 IHC (p), WB WB Image Western Blot analysis of NSMAF expression in transfected 293T cell line by NSMAF polyclonal antibody. A: Non-transfected lysate. B: NSMAF transfected lysate. 7.5% SDS PAGE antibody diluted at 1:500 IHC-P Image Immunohistochemical analysis of paraffin-embedded human T(gastric cancer) , using NSMAF, antibody at 1:100 dilution. 100 μL Log in to see 23至28个工作日
¥9,012.09
详细
非结合性 IHC (p), IHC, WB Immunohistochemistry-Paraffin: NSMAF Antibody [NBP1-31431] - Paraffin-embedded T(gastric CA), using antibody at 1:100 dilution. Western Blot: NSMAF Antibody [NBP1-31431] - Analysis of NSMAF expression in transfected 293T cell line by NSMAF polyclonal antibody. A: Non-transfected lysate. B: NSMAF transfected lysate. 7.5% SDS PAGE, antibody diluted at 1:500. 0.1 mL Log in to see 25至31个工作日
¥3,655.56
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非结合性 IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded Mouse intestines, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with NSMAF Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded Mouse stomach, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with NSMAF Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining. 100 μL Log in to see 14至17个工作日
¥2,610.23
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非结合性 IHC, IHC (p), WB Immunohistochemistry: NSMAF Antibody [NBP1-84736] - Staining of human colon shows moderate cytoplasmic positivity in glandular cells. Western Blot: NSMAF Antibody [NBP1-84736] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY418576) 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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非结合性 IHC, IHC (p) Immunohistochemistry: NSMAF Antibody [NBP1-84737] - Staining of human oral mucosa shows strong nuclear positivity in squamous epithelial cells. 0.1 mL Log in to see 28至35个工作日
¥3,591.24
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: NSMAF Antibody [NBP1-84735] - Staining of human cell line A-431 shows positivity in nucleoli. Immunohistochemistry-Paraffin: NSMAF Antibody [NBP1-84735] - Staining of human thyroid gland shows strong nuclear and cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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非结合性 IHC (p), WB   100 μL Log in to see 29至35个工作日
¥5,127.12
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通过反应活性、应用领域、克隆类型和共轭标记 NSMAF 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 抗体

  1. Human Polyclonal NSMAF Primary Antibody for WB - ABIN265263 : OBrien, Gellings, Guo, Barlow, Glembotski, Sabbadini: Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death. in Circulation research 2003 (PubMed)
    Show all 3 references for 265263

  2. Human Polyclonal NSMAF Primary Antibody for WB - ABIN4620368 : Ségui, Andrieu-Abadie, Adam-Klages, Meilhac, Kreder, Garcia, Bruno, Jaffrézou, Salvayre, Krönke, Levade: CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for 4620368

更多抗Neutral Sphingomyelinase (N-SMase) Activation Associated Factor的相互作用对抗体

Human Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) interaction partners

  1. The interaction of FAN with receptor for activated C-kinase 1 (RACK1 (显示 GNB2L1 抗体)) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN.

  2. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase (显示 SMPD1 抗体)

  3. Regulation of NSMAF by TNF-alpha (显示 TNF 抗体) involves PRKCD (显示 PKCd 抗体) in lung epithelial cells.

Mouse (Murine) Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) interaction partners

  1. FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor (显示 TNF 抗体).

  2. FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis.

  3. the role of FAN and IL-6 (显示 IL6 抗体) in the inflammatory response initiated by endotoxin, implicating TNFalpha (显示 TNF 抗体)

  4. FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC.

  5. The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in tumor necrosis factor (显示 TNF 抗体)-induced Cdc42 (显示 CDC42 抗体) activation and cytoskeleton reorganization.

  6. This is the first report to demonstrate that TNFalpha (显示 TNF 抗体)-induced sickness behavior is fully mediated by TNF-R1 (显示 TNFRSF1A 抗体) and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior

  7. these results indicate the involvement of FAN in TNF (显示 TNF 抗体)-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.

Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) 抗原简介

蛋白简介

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NSMAF

  • protein FAN (EDI_035100) 抗体
  • neutral sphingomyelinase (N-SMase) activation associated factor (NSMAF) 抗体
  • neutral sphingomyelinase (N-SMase) activation associated factor (Nsmaf) 抗体
  • AA959567 抗体
  • C630007J05 抗体
  • Fan 抗体

Protein level used designations for NSMAF

protein FAN , factor associated with N-SMase activation , factor associated with neutral sphingomyelinase activation

GENE ID SPECIES
5884688 Entamoeba dispar SAW760
8439 Homo sapiens
18201 Mus musculus
353233 Rattus norvegicus
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