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Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. 再加上，我们可以发Myoferlin 试剂盒 (7) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal MYOF Primary Antibody for ICC, IF - ABIN4337241
Volakis, Li, Ackerman, Mihai, Bechel, Summerfield, Ahn, Powell, Zielinski, Rosol, Ghadiali, Kniss: Loss of myoferlin redirects breast cancer cell motility towards collective migration. in PLoS ONE 2014
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This study is the first to report robust age associations for DNA methylation (显示 HELLS 抗体) in MYOF and DDO (显示 DDO 抗体), both of which have plausible functional roles in aging
Results demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients.
Myoferlin plays a key role in VEGFA (显示 VEGFA 抗体) secretion and impacts tumor-associated angiogenesis in human pancreas cancer.
MYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells.
These data provide the first evidence of myoferlin expression in solid human and mouse tumors.
Data indicate that dysferlin (显示 DYSF 抗体), otoferlin (显示 OTOF 抗体), and myoferlin do not merely passively adsorb to membranes but actively sculpt lipid bilayers.
High myoferlin expression is associated with breast cancer.
The effect of myoferlin on the expression of ZO-1 (显示 TJP1 抗体) in airway epithelial cells indicates its role in membrane fusion events that regulate cell detachment and apoptosis within the airway epithelium.
suggest a novel role of MYOF in breast tumor cell invasion and a potential reversion to an epithelial phenotype upon loss of MYOF
MYOF plays a previously unrecognized role in cancer cell invasion.
these findings demonstrate the importance of dysferlin (显示 DYSF 抗体) and myoferlin for transverse tubule function and in the genesis of muscular dystrophy.
Myoferlin gene knockdown not only decreases lipid vesicle fusion in EC but also attenuates Vascular Endothelial Growth Factor (VEGF) Receptor-2 (VEGFR-2) expression.
IGF1 (显示 IGF1 抗体) receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1 (显示 IGF1 抗体)
Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)
myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes.
myoferlin forms a complex with dynamin-2 (显示 DNM2 抗体) and VEGFR-2 (显示 KDR 抗体), which prevents CBL (显示 CBL 抗体)-dependent VEGFR-2 (显示 KDR 抗体) polyubiquitination and proteasomal degradation.
interaction of myoferlin with EHD2 (显示 EHD3 抗体) identifies molecular overlap between the endocytic recycling pathway and the machinery that regulates myoblast membrane fusion
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.
fer-1-like 3, myoferlin
, Fer-1-like protein 3
, fer-1-like protein 3