anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) 抗体

Histone methyltransferase that plays an essential role in early development and hematopoiesis. 再加上,我们可以发Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
大鼠 MLL1 MLL1 315606  
MLL1 214162 P55200
MLL1    
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 DB Dot blot analysis of Phospho-TJP2-S978 Antibody Phospho-specific Pab  on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. 400 μL Log in to see 10至11个工作日
$324.50
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非结合性 WB   100 μL Log in to see 2至3个工作日
$265.00
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非结合性 ELISA   200 μL Log in to see 11至16个工作日
$594.00
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APC ELISA   200 μL Log in to see 16 Days
$743.29
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FITC ELISA   200 μL Log in to see 16 Days
$743.29
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HRP ELISA   200 μL Log in to see 16 Days
$743.29
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PE ELISA   200 μL Log in to see 16 Days
$743.29
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Alkaline Phosphatase (AP) ELISA   200 μL Log in to see 16 Days
$743.29
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Biotin ELISA   200 μL Log in to see 16 Days
$743.29
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非结合性 WB   100 μL Log in to see 2至3个工作日
$510.36
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通过反应活性、应用领域、克隆类型和共轭标记 MLL1 抗体

特性 应用范围 宿主 克隆类型 标记
Mouse (Murine)


Human , ,


, , , , ,

更多抗Myeloid/lymphoid Or Mixed-Lineage Leukemia 1的相互作用对抗体

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) interaction partners

  1. Collectively, these data indicated that ATR (显示 ATR 抗体) or ATM (显示 ATM 抗体) inhibition represent potential therapeutic strategies for the treatment of AML (显示 RUNX1 抗体), especially MLL (显示 MLL 抗体)-driven leukemias.

  2. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL (显示 MLL 抗体)-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.

  3. NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体) interacts with MLL (显示 MLL 抗体) via the NUP98 (显示 NUP98 抗体) second FG repeat domain. In the absence of MLL (显示 MLL 抗体) (in knockout mice), NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体)-induced cell immortalization and leukemogenesis are severely inhibited. MLL (显示 MLL 抗体) is important for the recruitment of NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体) to the HOXA locus and for NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体)-induced HOXA gene expression. MLL (显示 MLL 抗体) is crucial for NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体) leukemia initiation.

  4. Atg5 (显示 ATG5 抗体)-dependent autophagy contributes to the development of acute myeloid leukemia (显示 BCL11A 抗体) in an MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体)-driven mouse model.

  5. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN 抗体) and DOT1L (显示 DOT1L 抗体) and suggest a molecular rationale for the simultaneous inhibition of the MLL (显示 MLL 抗体) fusion-AF4 complex and DOT1L (显示 DOT1L 抗体) for more effective treatment of MLL (显示 MLL 抗体)-rearranged leukemia.

  6. This study demonstrated that Kmt2a (显示 MLL 抗体) regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  7. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  8. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  9. HoxBlinc RNA Recruits Set1 (显示 SETD1A 抗体)/MLL (显示 MLL 抗体) Complexes to Activate Hox (显示 MSH2 抗体) Gene Expression Patterns and Mesoderm Lineage Development.

  10. MLL1 and DOT1L (显示 DOT1L 抗体) cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A 抗体).

Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) 抗原简介

蛋白简介

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).

Gene names and symbols associated with MLL1

  • lysine methyltransferase 2A (Kmt2a) 抗体
  • lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
  • 6430520K01 抗体
  • ALL-1 抗体
  • All1 抗体
  • Cxxc7 抗体
  • HRX 抗体
  • HTRX1 抗体
  • mKIAA4050 抗体
  • Mll 抗体
  • Mll1 抗体

Protein level used designations for MLL1

Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene) , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia 1 , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax Drosophila , zinc finger protein HRX

GENE ID SPECIES
315606 Rattus norvegicus
214162 Mus musculus
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