Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) ELISA试剂盒

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. 再加上,我们可以发Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 抗体 (52)Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 蛋白 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 MLL MLL 4297 Q03164
小鼠 MLL MLL 214162 P55200
大鼠 MLL MLL 315606  

适于 Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 相互作用对的更多 ELISA 试剂盒

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN ELISA试剂盒) and DOT1L (显示 DOT1L ELISA试剂盒) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (显示 DOT1L ELISA试剂盒) for more effective treatment of MLL-rearranged leukemia.

  3. this indicates that DOT1L (显示 DOT1L ELISA试剂盒) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (显示 DOT1L ELISA试剂盒) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  4. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (显示 HIF1A ELISA试剂盒) and histone acetyltransferase p300 (显示 EP300 ELISA试剂盒) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  5. MLL1 and MLL2 (显示 MLL2 ELISA试剂盒) collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (显示 CBX2 ELISA试剂盒) response elements.

  7. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  8. MLL gene rearrangement is associated with acute lymphocytic leukemia.

  9. Our data thus extend MLL1 function to H3K4 methylation and PD-L1 (显示 CD274 ELISA试剂盒) transcription activation in pancreatic cancer cells.

  10. KMT2A gene rearrangement is associated with acute megakaryoblastic leukemia in non-Down syndrome.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN ELISA试剂盒) and DOT1L (显示 DOT1L ELISA试剂盒) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (显示 DOT1L ELISA试剂盒) for more effective treatment of MLL-rearranged leukemia.

  2. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  3. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  4. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  5. HoxBlinc RNA Recruits Set1 (显示 SETD1A ELISA试剂盒)/MLL Complexes to Activate Hox (显示 MSH2 ELISA试剂盒) Gene Expression Patterns and Mesoderm Lineage Development.

  6. MLL1 and DOT1L (显示 DOT1L ELISA试剂盒) cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

  7. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors

  8. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  9. We have demonstrated that the Mll1 gene is critical to Th1 (显示 HAND1 ELISA试剂盒) differentiation in humans and mice

  10. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) 抗原简介

Antigen Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) 抗体
  • lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
  • 6430520K01 抗体
  • ALL-1 抗体
  • All1 抗体
  • Cxxc7 抗体
  • HRX 抗体
  • HTRX1 抗体
  • mKIAA4050 抗体
  • Mll 抗体
  • MLL/GAS7 抗体
  • Mll1 抗体
  • MLL1A 抗体
  • TET1-MLL 抗体
  • TRX1 抗体
  • WDSTS 抗体

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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