Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) ELISA试剂盒

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. 再加上,我们可以发Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 抗体 (54)Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 蛋白 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 MLL MLL 4297 Q03164
小鼠 MLL MLL 214162 P55200
大鼠 MLL MLL 315606  
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适于 Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 相互作用对的更多 ELISA 试剂盒

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. The most common KMT2A breakpoint region was intron/exon 9 (3/8 patients), followed by intron/exon 11 and 10.

  2. study describes 2 patients with Wiedemann-Steiner syndrome who presented with variable severity; findings revealed a de novo nonsense mutation, p.Gln1978*, of KMT2A in the former, and a missense mutation, p.Gly1168Asp, in the latter

  3. Comprehensive genetic analysis of donor cell derived leukemia with KMT2A rearrangement

  4. Data show that expression of myeloid-lymphoid leukemia protein (MLL) fusion protein does neither influence DNA signaling nor DNA double strand breaks (DNA-DSBs) repair.

  5. In this case study, we diagnosed t-MN with KMT2A rearrangement in a patient with history of B-ALL with 9p deletion and gain of X chromosome. Unusual features associated with this case are discussed

  6. Identification of novel biomarkers for MLL-translocated acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

  7. Collectively, these data indicated that ATR (显示 ANTXR1 ELISA试剂盒) or ATM (显示 ATM ELISA试剂盒) inhibition represent potential therapeutic strategies for the treatment of AML (显示 RUNX1 ELISA试剂盒), especially MLL-driven leukemias.

  8. we report two boys with novel KMT2A mutations from Chinese origin for the first time. They do not show one of the characteristic WDSTS phenotype, cubiti hypertrichosis. Instead, both of them had absent palmar proximal transverse crease. The feature was not linked to WDSTS patients previously. Our findings extend the WDSTS phenotypic spectrum.

  9. Whole exome sequencing allowed identifying a previously unreported de novo KMT2A missense mutation affecting the DNA binding domain of the methyltransferase. This finding expands the clinical phenotype associated with KMT2A mutations to include immunodeficiency and epilepsy as clinically relevant features for this disorder.

  10. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. Collectively, these data indicated that ATR (显示 ATR ELISA试剂盒) or ATM (显示 ATM ELISA试剂盒) inhibition represent potential therapeutic strategies for the treatment of AML (显示 RUNX1 ELISA试剂盒), especially MLL-driven leukemias.

  2. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.

  3. NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) interacts with MLL via the NUP98 (显示 NUP98 ELISA试剂盒) second FG repeat domain. In the absence of MLL (in knockout mice), NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒)-induced cell immortalization and leukemogenesis are severely inhibited. MLL is important for the recruitment of NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) to the HOXA locus and for NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒)-induced HOXA gene expression. MLL is crucial for NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) leukemia initiation.

  4. Atg5 (显示 ATG5 ELISA试剂盒)-dependent autophagy contributes to the development of acute myeloid leukemia (显示 BCL11A ELISA试剂盒) in an MLL-AF9 (显示 MLLT3 ELISA试剂盒)-driven mouse model.

  5. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN ELISA试剂盒) and DOT1L (显示 DOT1L ELISA试剂盒) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (显示 DOT1L ELISA试剂盒) for more effective treatment of MLL-rearranged leukemia.

  6. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  7. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  8. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  9. HoxBlinc RNA Recruits Set1 (显示 SETD1A ELISA试剂盒)/MLL Complexes to Activate Hox (显示 MSH2 ELISA试剂盒) Gene Expression Patterns and Mesoderm Lineage Development.

  10. MLL1 and DOT1L (显示 DOT1L ELISA试剂盒) cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) 抗原简介

Antigen Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine methyltransferase 2A (KMT2A) 抗体
  • lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
  • lysine methyltransferase 2A (Kmt2a) 抗体
  • 6430520K01 抗体
  • ALL-1 抗体
  • All1 抗体
  • Cxxc7 抗体
  • HRX 抗体
  • HTRX1 抗体
  • mKIAA4050 抗体
  • Mll 抗体
  • MLL/GAS7 抗体
  • Mll1 抗体
  • MLL1A 抗体
  • TET1-MLL 抗体
  • TRX1 抗体
  • WDSTS 抗体

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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