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The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. 再加上，我们可以发Myelin Basic Protein 试剂盒 (62) 和 Myelin Basic Protein 蛋白 (28)和数多这个蛋白质的别的产品。
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Human Polyclonal MBP Primary Antibody for ICC, IHC - ABIN1078364
Bleyer, Curths, Dahlmann, Wichmann, Bauer, Moritz, Braun, Knauf, Kaup, Gruber-Dujardin: Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus). in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2016
Rat (Rattus) Polyclonal MBP Primary Antibody for ELISA, WB - ABIN1574105
Kraitsy, Uecal, Grossauer, Bruckmann, Pfleger, Ropele, Fazekas, Gruenbacher, Patz, Absenger, Porubsky, Smolle-Juettner, Tezer, Molcanyi, Fasching, Schaefer: Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function. in PLoS ONE 2014
t-PA (显示 PLAT 抗体) binds to Lys91 in the MBP (显示 MBL2 抗体) NH2-terminal region and PLG (显示 PLG 抗体) binds to Lys122 in the MBP (显示 MBL2 抗体) COOH-terminal region. This proximity promotes the activation of PLG (显示 PLG 抗体) by t-PA (显示 PLAT 抗体).
Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP (显示 MBL2 抗体) suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery
Results provide novel insights into the role of genetic variation within the MBP (显示 MBL2 抗体) gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors
Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.
This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1 (显示 NDEL1 抗体)) mRNA levels in FEP patients compared with controls.
myelin basic protein has a role in activating CD4 (显示 CD4 抗体)+ and CD8 (显示 CD8A 抗体)+ T lymphocytes in multiple sclerosis
B cells from relapsing-remitting multiple sclerosis patients produce TNFa (显示 TNF 抗体) and IL6 (显示 IL6 抗体), and present MBP85-99 peptide
IL-17 (显示 IL17A 抗体)- and IL-22 (显示 IL22 抗体)-secreting myelin specific CD4 (显示 CD4 抗体)(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis.
Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions.
Reduced myelin basic protein-induced CD4 (显示 CD4 抗体)+ T-cell autoreactivity in interferon-beta (显示 IFNB1 抗体)-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10 (显示 IL10 抗体)
Concentrations of MBP did not increase after injury in all age groups
results provide a detailed picture of the MBP-CaM (显示 CALM PLURAL_@27095@) interaction, including a 3D model of the complex between full-length proteins
MBP-hydrolyzing antibodies may play an important role in multiple sclerosis pathogenesis
Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase (显示 CDK7 抗体) activities.
trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.
formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability
results provide a detailed picture of the MBP-CaM (显示 KRIT1 PLURAL_@27095@) interaction, including a 3D model of the complex between full-length proteins
MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.
Bovine MBP priming reduces expression of Foxp3 (显示 FOXP3 抗体) via nitric oxide in inducible nitric oxide synthase (显示 NOS2 抗体)-deficient mouse T cells.
investigation of bovine myelin basic protein binding to triphosphoinositide
There is a developmental regulation of posttranslationally modified forms of myelin basic protein into specific membrane microdomains.
These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta (显示 GSK3b 抗体) and for the GSK-3beta (显示 GSK3b 抗体)-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.
to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair
Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.
Results suggest that GAL (显示 GAL 抗体) is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters
Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.
Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.
Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs).
Disappearance of 21.5 pMBP (显示 PGRMC2 抗体) corresponded to demyelination and its reappearance corresponded to prevention of demyelination.
Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha (显示 PKCa 抗体)-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
Myelin basic protein cleaves cell adhesion molecule (显示 MCAM 抗体) L1 and promotes neuritogenesis and cell survival.
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
myelin basic protein
, myelin A1 protein
, myelin membrane encephalitogenic protein
, 20 kDa microtubule-stabilizing protein
, microtubule-stabilizing protein
, Golli-Mbp; myelin basic protein
, Golli-Mbp; myelin basic protein; myelin basic protein S
, MBP S
, myelin basic protein Golli-mbp
, myelin basic protein S
, myelin deficient